Studies of the Metabolic Basis of the ATP-DPG Differences in Genetically Selected High and Low ATP-DPG Rat Strains
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Red cell ATP and DPG show considerable quantitative variability in human populations. Because DPG and ATP bind to hemoglobin and affect oxygen transport, quantitative variability in these intermediates may result in functional differences in the red cells of various individuals. Earlier work in our laboratory showing a negative correlation between DPG and hemoglobin levels (Eaton and Brewer, 1968) suggests that this is so.
KeywordsGlycolytic Intermediate Quantitative Variability Mixed Venous Oxygen Tension Fructose Diphosphate Hereditary Difference
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- Brewer, G.J., Oelshlegel, F.J., Jr., and Eaton, J.W. (1972). Biochemical, Physiological, and Genetic Factors in the Regulation of Mammalian Erythrocyte Metabolism and DPG Levels. In “IVth Alfred Benzon Symposium”, Munksgaard, Copenhagen, In press.Google Scholar
- Minakami, S., Suzuki, C., Saito, T., and Yoshikawa, H. (1965). Studies on Erythrocyte Glycolysis I. Determination of the Glycolytic Intermediates in Human Erythrocytes. J. Biochem. 58: 543.Google Scholar
- Williamson, J.R. (1970). General Features of Metabolic Control as Applied to the Erythrocyte. In “Red Cell Metabolism a nd Function” ( G.J. Brewer, ed.) pp. 117–136, Plenum Press, New York.Google Scholar