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Effect of Natural Teratogens in Poisonous Plants on Fetal Development in Domestic Animals

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Drugs and Fetal Development

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 27))

Abstract

Many poisonous range plants common in the diet of domestic livestock possess teratogenic potential. Some congenital deformities, once thought to be of genetic origin, are now known to be caused by the teratogens of these plants. The period of maternal ingestion required to produce congenital defects varies among plants, from a single dose on one day to prolonged periods of one to two weeks. Knowledge of the duration of maternal ingestion required for the teratogenic effect to be realized has aided in formulating postulates on the mechanism of action. In some instances, the teratogens have been isolated and structurally characterized, permitting further postulation on the mechanism. Range plants known to produce congenital deformities include Lupinus, Astragalus, Veratrum, Leucaena, Lathyrus, and Indigofera. Those strongly suspected include Nicotiana, Coniium, Thermopsis, Cytisus, Sophora and Senecio.

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References

  1. KINGSBURY, J.M. “Poisonous Plants of the United States and Canada.” Prentice Hall. Englewood Cliffs, N.J. (1964).

    Google Scholar 

  2. VANKAMPEN, K.R. & JAMES, L.F. Path. Vet. 6: 413, 1969.

    CAS  Google Scholar 

  3. JAMES, L.F., VANKAMPEN, K.R. & HARTLEY, W.J. Path. Vet. 7: 116, 1970.

    Article  CAS  Google Scholar 

  4. JAMES, L.F. & VANKAMPEN, K.R. J. Am. Vet. Med. Assn. 158: 614, 1971.

    CAS  Google Scholar 

  5. FRAPS, G.S. & CARLYLE, E.C. Bull. Texas Agr. Exp. Sta. 537: 1, 1936.

    Google Scholar 

  6. JAMES, L.F., SHUPE, J.L., BINNS, W. & KEELER, R.F. Am. J. Vet. Res. 28: 1379, 1967.

    PubMed  CAS  Google Scholar 

  7. JAMES, L.F., KEELER, R.F., & BINNS, W. Am. J. Vet. Res. 30: 377, 1969.

    PubMed  CAS  Google Scholar 

  8. KEELER, R.F., JAMES, L.F., BINNS, W. & SHUPE, J.L. Can. J. Comp. Med. Vet. Sci. 31: 334, 1967.

    PubMed  CAS  Google Scholar 

  9. KEELER, R.F. & JAMES, L.F. Can. J. Comp. Med. (Unpublished data.)

    Google Scholar 

  10. KIM, C.S. & HILL, C.H. Biochem. Biophys. Res. Comm. 24: 395, 1966.

    Article  PubMed  CAS  Google Scholar 

  11. MILLER, E.J., MARTIN, G.R., MECCA, C.E., ET AL. J. Biol. Chem. 240: 3623, 1965

    PubMed  CAS  Google Scholar 

  12. NARA, S., IGAUE, I., GOMES, B. ET AL. Biochem. Biophys. Res. Comm. 23: 324, 1966.

    Article  PubMed  CAS  Google Scholar 

  13. O’DELL, B.L., ELSDEN, D.F., THOMAS, J., ET AL. Biochem. J. 96: 35P, 1965.

    Google Scholar 

  14. PAGE, R.C., BENDITT, E.P. & KIRKWOOD, C.R. Biochem. Biophys. Res. Comm. 33:752

    Google Scholar 

  15. PINNEL, S.R. & MARTIN, G.R. Proc. Nati. Acad. Sci. 61: 708, 1968.

    Article  Google Scholar 

  16. DASLER, W. Proc. Soc. Expt. Biol. Med. 85: 485, 1954.

    CAS  Google Scholar 

  17. LEVENE, C.I. J. Expt. Med. 114: 245, 1961.

    Article  Google Scholar 

  18. NABER, E.C., SCOTT, K. & JOHNSON, R.M. Fed. Proc. 26: 121, 1967.

    PubMed  CAS  Google Scholar 

  19. KLAGES, A. Berichte. 36: 1506, 1903.

    CAS  Google Scholar 

  20. DASLER, W. Proc. Soc. Expt. Biol. Med. 88: 196, 1955.

    CAS  Google Scholar 

  21. BOHLMANN, F. & SHUMAN, D. “The Alkaloids.“ Vol. IX, Academic Press, New York (1967).

    Google Scholar 

  22. SHUPE, J.L., BINNS, W., JAMES, L.F. & KEELER, R.F. J. Amer. Vet. Med. Assoc. 151: 198, 1967.

    CAS  Google Scholar 

  23. SHUPE, J.L., BINNS, W., JAMES, L.F. & KEELER, R.F. Aust. J. Agr. Res. 19: 335, 1968.

    Article  Google Scholar 

  24. CHANG, C.Y., WITSOHI, E. & PONSETI, I.V. Proc. Soc. Expt. Biol. Med. 90: 45, 1955.

    CAS  Google Scholar 

  25. HERD, K., ORBISON, J.L. Arch. Pathol. 82: 60, 1966.

    Google Scholar 

  26. ROSENBURG, E.E. Nature 180: 706, 1957.

    Article  Google Scholar 

  27. STAMLER, F.W. Proc. Soc. Expt. Biol. Med. 90: 294, 1955.

    CAS  Google Scholar 

  28. KEELER, R.F., BINNS, W., JAMES, L.F., SHUPE, J.L. Can. J. Comp. Med. 33: 89, 1969.

    PubMed  CAS  Google Scholar 

  29. LANDAUER, W. J. Expt. Zool. 243: 107, 1960.

    Article  Google Scholar 

  30. BINNS, W. Unpublished Observations. Logan, Utah (1971).

    Google Scholar 

  31. BINNS, W., JAMES, L.F., SHUPE, J.L., ET AL. Am. J. Vet. Res. 24: 1164, 1963.

    PubMed  CAS  Google Scholar 

  32. BINNS, W., SHUPE, J.L., KEELER, R.F., & JAMES, L.F. J. Am. Vet. Med. Assoc. 147: 839, 1965.

    PubMed  CAS  Google Scholar 

  33. KEELER, R.F. & BINNS, W. Can. J. Biochem. 44: 819, 1966.

    PubMed  CAS  Google Scholar 

  34. KEELER, R.F. & BINNS, W. Can. J. Biochem. 44: 829, 1966.

    PubMed  CAS  Google Scholar 

  35. KEELER, R.F. & BINNS, W. Teratology 1: 5, 1968.

    Article  PubMed  CAS  Google Scholar 

  36. KEELER, R.F. Phytochemistry 7: 303, 1968.

    Article  CAS  Google Scholar 

  37. KEELER, R.F. Phytochemistry 8: 223, 1969.

    Article  CAS  Google Scholar 

  38. KEELER, R.F. Steroids 13: 579, 1969.

    Article  PubMed  CAS  Google Scholar 

  39. KEELER, R.F. Unpublished data.

    Google Scholar 

  40. KEELER, R.F. Teratology 3: 175, 1970.

    Article  PubMed  CAS  Google Scholar 

  41. KEELER, R.F. Proc. Soc. Expt. Biol. Med. 136: 1174, 1971.

    CAS  Google Scholar 

  42. KEELER, R.F. Teratology 3: 169, 1970.

    Article  PubMed  CAS  Google Scholar 

  43. ALLFREY, V. Fed. Proc. 28: 249, 1969.

    Google Scholar 

  44. SLUYSER, M. Biochem. Biophys. Acta. 182: 235, 1969.

    PubMed  CAS  Google Scholar 

  45. O’MALLEY, B.W. Trans. N.Y. Acad. Sci. 31: 478, 1969.

    Article  PubMed  Google Scholar 

  46. MASAMUNE, T., SATO, N., KOBAYASHI, L., ET AL. Tertahedron 23: 1591, 1967.

    Article  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Agricultural Research Service Veterinary Sciences Research Division, United States Department of Agriculture, Logan, Utah, USA

    Richard F. Keeler

Authors
  1. Richard F. Keeler
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Editor information

Editors and Affiliations

  1. Israel Institute for Biological Research and Tel-Aviv University Medical School, Ness-Ziona, Israel

    Marcus A. Klingerg (Head, Department of Epidemiology and Deputy Scientific Director) (Head, Department of Epidemiology and Deputy Scientific Director)

  2. Laboratory of Developmental Pathology J. Casper Department of Pathology, Beilinson Hospital and Tel-Aviv University Medical School, Petah-Tikva, Israel

    Armand Abramovici (Director) (Director)

  3. Birth Defects Clinic Departments of Pediatrics A and Pediatric Research, Kaplan Hospital (affiliated with the Hebrew University and Hadassah Medical School, Jerusalem), Rehovot, Israel

    Juan Chemke (Director) (Director)

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© 1972 Plenum Press, New York

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Keeler, R.F. (1972). Effect of Natural Teratogens in Poisonous Plants on Fetal Development in Domestic Animals. In: Klingerg, M.A., Abramovici, A., Chemke, J. (eds) Drugs and Fetal Development. Advances in Experimental Medicine and Biology, vol 27. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3219-0_10

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  • DOI: https://doi.org/10.1007/978-1-4684-3219-0_10

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3221-3

  • Online ISBN: 978-1-4684-3219-0

  • eBook Packages: Springer Book Archive

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