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Alteration of Renin Release by Stress and Adrenergic Receptor and Related Drugs in Unanesthetized Rats

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Comparative Pathophysiology of Circulatory Disturbances

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 22))

Abstract

Appropriate physiologic responses of serum renin activity (SRA) in the unanesthetized rat (1) suggest this highly useful laboratory animal for pharmacologic studies of renin release. Adrenergic mediation of renin release has been suggested by results of previous investigations in man (2—4), anesthetized animals (5—11) and in vitro studies (12). Anesthesia induces renin release which can explain previously reported unique qualities of the rat renin-angiotensin-aldosterone systems (1). As a component of the development of model systems, for study of renin release, we have systematically evaluated the effects of adrenergic agonist and blocking drugs and ganglionic blocking and vasodilating agents on SRA in vivo in the unanesthetized rat. We then extended the investigations to determine the effects of beta-adrenergic blockade on renin release induced by diet and the stresses of anesthesia and swimming exercise.

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Author information

Authors and Affiliations

  1. Department of Pharmacology, Hoffmann-LaRoche Inc., Nutley, New Jersey, 07110, USA

    William A. Pettinger M.D. & Loraine Augusto B.S

  2. Special Treatment Unit, Beth Israel Medical Center, Newark, New Jersey, 07112, USA

    Arthur S. Leon M.D

Authors
  1. William A. Pettinger M.D.
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  2. Loraine Augusto B.S
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  3. Arthur S. Leon M.D
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Editor information

Editors and Affiliations

  1. Department of Pathology, University of California at San Diego, La Jolla, California, USA

    Colin M. Bloor

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© 1972 Plenum Press, New York

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Pettinger, W.A., Augusto, L., Leon, A.S. (1972). Alteration of Renin Release by Stress and Adrenergic Receptor and Related Drugs in Unanesthetized Rats. In: Bloor, C.M. (eds) Comparative Pathophysiology of Circulatory Disturbances. Advances in Experimental Medicine and Biology, vol 22. Springer, New York, NY. https://doi.org/10.1007/978-1-4684-3213-8_7

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  • DOI: https://doi.org/10.1007/978-1-4684-3213-8_7

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  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4684-3215-2

  • Online ISBN: 978-1-4684-3213-8

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