Differentiation of Macrophage Antigen(s) in Mouse Bone Marrow and Buffy Coat Cultures

  • M. Virolainen
  • A. Lahti
  • P. Häyry
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)


Kinetic studies have demonstrated that the mononuclear phagocytic cells or macrophages of serous cavities, lung alveoli and connective tissue originate from precursor cells (promonocytes) in the bone marrow (1–3). These cells give rise to the peripheral blood monocytes, which constitute a mobile pool capable of differentiating further into macrophages at different sites.


Bone Marrow Cell Buffy Coat Peripheral Blood Monocyte Bone Marrow Culture Peritoneal Exudate Cell 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • M. Virolainen
    • 1
  • A. Lahti
    • 1
  • P. Häyry
    • 1
  1. 1.Laboratory of Immunobiology, III Department of PathologyUniversity of HelsinkiHelsinki 29Finland

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