Pathomechanism of Increased RES Activity in Rats Bearing Yoshida Sarcoma

Abstract

It was observed in rats bearing subcutaneous Yoshida sarcoma that the growth of the tumors is associated with considerable splenomegaly. Considering that in the opinion of Andreini et al. /1/ this splenomegaly of the tumor bearing animals is due to an immunological reaction and this view has recently been confirmed by other authors /2, 3/, it seemed worth while to investigate the immunological relations of the Yoshida sarcoma. The question seemed all the more promising as Scheiforth et al. /4/ have reported that their rats, bearing subcutaneous Yoshida sarcoma, did not demonstrate an isoimmune response and that they could not observe either a tumor inhibitory or transplantation reaction. Circulating antibodies were not present either in the serum of the tumor bearing animals.