Pathomechanism of Increased RES Activity in Rats Bearing Yoshida Sarcoma
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It was observed in rats bearing subcutaneous Yoshida sarcoma that the growth of the tumors is associated with considerable splenomegaly. Considering that in the opinion of Andreini et al. /1/ this splenomegaly of the tumor bearing animals is due to an immunological reaction and this view has recently been confirmed by other authors /2, 3/, it seemed worth while to investigate the immunological relations of the Yoshida sarcoma. The question seemed all the more promising as Scheiforth et al. /4/ have reported that their rats, bearing subcutaneous Yoshida sarcoma, did not demonstrate an isoimmune response and that they could not observe either a tumor inhibitory or transplantation reaction. Circulating antibodies were not present either in the serum of the tumor bearing animals.
KeywordsHistological Study Immunological Reaction Tumor Bearing Tumor Bear Animal Enlarge Spleen
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