Virus Induced Malignant Lymphome in Mice Dependent on a RES ‘Conditioned’ by Chronic Parasitic Infection (P. Berghei)

  • C. Jerusalem
  • P. Jap
  • W. Eling
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)


Burkitt’s lymphoma (BL) is known to be common in regions where holo-endemic or hyperendemic malarial conditions exist. It has been postulated (1) that on the base of intense and prolonged malarial infection the lymphoreticular system (LRS) may be prone to malignant change in the presence of, or induced by, some viruses This hypothesis would be supported by the finding that all BL patients have high antibody titers to the Epstein-Barr virus (2), and that the EB virus could be demonstrated in tissue cultures set up from Burkitt lymphomas (3).


Virus Particle Malaria Infection Swiss Mouse Malarial Infection Milk Diet 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Kafuko, G.W. and D.P. Burkitt, Int. J. Cancer, 6:1, 1970.PubMedCrossRefGoogle Scholar
  2. 2.
    Levy, J.A. and G. Henle, J. Bact., 92:2755 1966.Google Scholar
  3. 3.
    Epstein, M.A., B.G. Achong and Y.M. Barr, Lancet, 1:702, 1964.PubMedCrossRefGoogle Scholar
  4. 4.
    Jerusalem, C., Z. Tropenmed. Parasit., 19:94, 1968.Google Scholar
  5. 5.
    Jerusalem, C., in: Lymphatic Tissue and Germinal Centers in Immune Response, p. 497, Plenum Press, 1969.Google Scholar
  6. 6.
    Burghouts, J.T., Centrale Drukkerij N.V., Nijmegen, 1970.Google Scholar
  7. 7.
    Dmochowski, L., C.E. Grey, and L. Gross, in: Radiation Biology and Cancer, Symposium on Fundamental Cancer Research, p. 382. University of Texas Press, 1958.Google Scholar
  8. 8.
    Kretschmar, W. and C. Jerusalem, Z. Tropenmed. Parasit., 14:279, 1963.Google Scholar
  9. 9.
    Jerusalem, C. and W. Kretschmar, Anat. Anz. Erg.H., 113:95, 1964.Google Scholar
  10. 10.
    Jerusalem, C. and U. Heinen, Z. Tropenmed. Parasit., 16:377, 1965.Google Scholar
  11. 11.
    Mungyerova, G. and C. Jerusalem, Z. Zellforsch., 71:364, 1966.CrossRefGoogle Scholar
  12. 12.
    Jerusalem, C. and G. Mungyerova, Morphol. Jahrbuch, 111:59, 1967.Google Scholar
  13. 13.
    Eling, W. and C. Jerusalem, Anat. Anz. Erg. H., 121:197, 1968.Google Scholar
  14. 14.
    Jerusalem, C., Z. Tropenmed. Parasit., 19:401, 1968.Google Scholar
  15. 15.
    Sengers, R., C. Jerusalem, and W.H. Doesburg, J. Exp. Parasit., (in press).Google Scholar
  16. 16.
    De Harven, E., in: Tumors Induced by Viruses: Ultrastructural studies, p. 183. New York and London: Academic Press, 1962.Google Scholar
  17. 17.
    Bernhard, W., in: Cellular Injury, p. 209, London: J. & A. Churchill, 1964.Google Scholar
  18. 18.
    Ames, R.P. and R.C. Rubin, Cancer Research, 30:1142, 1970.PubMedGoogle Scholar
  19. 19.
    Zur Hausen, H. and H. Schulte-Holthausen, Nature, 227:245, 1970.PubMedCrossRefGoogle Scholar
  20. 20.
    Metcalf, D., the Thymus: Its role in Immune REsponse, Leukemia Development and Carcinogenesis. Springer, Berlin-Heidelberg-New York, 1966.Google Scholar
  21. 21.
    Jap, P. and C. Jerusalem, this volume.Google Scholar
  22. 22.
    Jerusalem, C., M.N. v.d. Heyde, P. Jap, J.W. Reinking, W.J.H. Schmidt, R. Bilski and F.A. Tjebbes, IIIrd Int. Congr. Transpl. Soc. 1970 (in press).Google Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • C. Jerusalem
    • 1
  • P. Jap
    • 1
  • W. Eling
    • 1
  1. 1.Laboratory of Cyto-HistologyUniversity of NijmegenThe Netherlands

Personalised recommendations