Macrophage Recognition Mechanisms: Clinical and Experimental Considerations

  • N. R. Di Luzio
  • J. C. Pisano
  • N. K. Salky
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)


Phagocytosis is an active process dependent upon both cellular activity (1–4) and humoral recognition factors (HRF) (5–10). The latter are essential for the expression of the discriminative actions of macrophages. Alterations in either the cellular or humoral components of the RES manifest themselves in altered intravascular clearance of colloidal materials (7,8,11,12). In addition to altered intravascular clearance rates, depression of reticuloendothelial (FE) function, by either alterations of cellular activity or depletion of HRF, is also associated with a decreased production of humoral antibodies (13,14) and cellular transplant reactions (15). Conversely, RES stimulation is associated with increased humoral (16) and cellular immunity (15). It is clear from these and other studies that the RES constitutes the afferent limb of the immune response.


Kupffer Cell Lipid Emulsion Liver Slice Normal Human Serum Human Alveolar Macrophage 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • N. R. Di Luzio
    • 1
  • J. C. Pisano
    • 1
  • N. K. Salky
    • 1
    • 2
  1. 1.Department of PhysiologyTulane University School of MedicineNew OrleansUSA
  2. 2.Department of MedicineUniversity of Tennessee Medical UnitsMemphisUSA

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