The Behaviour of Macrophages in Lung Cultures after Exposure to Cigarette Smoke. Evidence for Selective Inhibition by Particulate Matter and Stimulation by the Gas Phase of Cell Metabolism of Alveolar Macrophages

  • Cecile Leuchtenberger
  • Rudolf Leuchtenberger
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)


In contrast to the extensive experimental work on the biological activity of cigarette smoke condensates or extracts, there are few experimental investigations concerned with the biological effects of fresh native cigarette smoke itself on animals, tissues or cells. Data obtained with fresh cigarette smoke would appear to be more directly related to the important problem of the role of cigarette smoking in the genesis of pathologic changes in humans than data obtained with cigarette smoke condensates or extracts. For a number of years, therefore, we have used two types of model systems:
  1. 1

    Inhalation studies in mice with fresh cigarette smoke (1,2).

  2. 2

    Exposure of mouse cell, tissue and organ cultures to puffs of fresh cigarette smoke (3,4,5).



Cigarette Smoke Alveolar Macrophage Activate Charcoal Epithelioid Cell Golden Hamster 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Leuchtenberger, C., and R. Leuchtenberger, Z.Präventivmed., 13:122, 1968.CrossRefGoogle Scholar
  2. 2.
    Leuchtenberger, C., and R.Leuchtenberger, Proc. of the Conference on Morphology of Experimental Respiratory Carcinogenesis, to be published by the U.S. Atomic Energy Commission’s Division of Technical Information, as part of the AEC’s Symposium Series. In press.Google Scholar
  3. 3.
    Leuchtenberger, C., and R. Leuchtenberger, Cancer Res. 29:862, 1969.PubMedGoogle Scholar
  4. 4.
    Leuchtenberger, C., M. Schumacher and T. Haldimann, Z.Präventivmed., 13:130, 1968.CrossRefGoogle Scholar
  5. 5.
    Leuchtenberger, C., and R. Leuchtenberger, Exper. Cell Res. (special issue in honour of Prof.T.Caspersson, in press).Google Scholar
  6. 6.
    Green, G.M., and D. Carolin, New Engl.J. of Med, 276:421, 1967.CrossRefGoogle Scholar
  7. 7.
    Myrvik, Q.N., F.S. Leake and B. Fariss, J. Immun. 86:128, 1961.PubMedGoogle Scholar
  8. 8.
    Myrvik, Q.N., and D.G. Evans, Arch.Environ.Health, 14:92, 1967.PubMedGoogle Scholar
  9. 9.
    Leuchtenberger, C., General Cytochemical Methods, vol. 1 (Academic Press Inc., New York, 1957) 221.Google Scholar
  10. 10.
    Feinendegen, L., Tritium-labeled molecules in biology and medecine (Academic Press, Neu York and London, 1967).Google Scholar
  11. 11.
    Eichel, B., and H.A. Shahrik, Science, 166:1424, 1969.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Cecile Leuchtenberger
    • 1
  • Rudolf Leuchtenberger
    • 1
  1. 1.Swiss Institute for Experimental Cancer ResearchLausanneSwitzerland

Personalised recommendations