Protective Effect of Reticuloendothelial System Stimulants in Combination with Chloroquine on PlasmodiumBerghei Infection in Mice

  • Emile G. Bliznakov
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)


The importance of the reticuloendothelial system (RES) in the case of protozoan infections and particularly in malaria has long been recognized but never fully demonstrated. Recently, it was shown that stimulation of the RES alone is unable to increase resistance in mice against Plasmodium berghei infection.

Based on an assumption expressed earlier that the therapeutic effect of antimalarial drugs is not only directed against the malarial parasites but also requires participation of the RES, we attempted to demonstrate this relationship by using a combination of an antimalarial drug (Aralen-chloroquine hydrochloride) and an RES-stimulating agent (cholesteryl oleate, glucan or coenzyme Q10).

The results of these studies show that pretreatment with low doses of chloroquine combined with RES-stimulating agents results in increased survivorship, prolonged survival time and reduced parasitemia in blood-transferred Plasmodium berghei infection in mice. The described effects were strongly dependent on the dose and the time of administration.


Antimalarial Drug Reticuloendothelial System Malarial Infection Malarial Parasite Plasmodium Berghei 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Goble, F. C. and I. Singer, Ann. N. Y. Acad. Sci., 88:149, 1960.CrossRefGoogle Scholar
  2. 2.
    Arima, J., Fukuoka Acta Med., 27:12, 1934.Google Scholar
  3. 3.
    Kritschewski, I. L. and L. W. Demidowa, Zschr. Immunitätsforsch. Exp. Ther., 84:14, 1934.Google Scholar
  4. 4.
    Trager, W., Am. J. Hyg., 34:141, 1941.Google Scholar
  5. 5.
    Taliaferro, W. H., L. G. Taliaferro and E. L. Simmons, J. Inf. Dis., 77:158, 1945.CrossRefGoogle Scholar
  6. 6.
    Bennison, B. E. and G. R. Coatney, Public Health Repts., 60: 127, 1945.CrossRefGoogle Scholar
  7. 7.
    Singer, I., J. Inf. Dis., 94:237, 1954.CrossRefGoogle Scholar
  8. 8.
    Yoeli, M., Bull. Soc. Path. Exotique, 59:593, 1966.Google Scholar
  9. 9.
    Martin, L. K., A. Einheber, E. H. Sadun and R. E. Wren, Exp. Parasitol., 20:186, 1967.PubMedCrossRefGoogle Scholar
  10. 10.
    Nussenzweig, R. S., Exp. Parasitol., 21:224, 1967.PubMedCrossRefGoogle Scholar
  11. 11.
    MacGregor, R. R., J. N. Sheagren and S. M. Wolff, J. Immunol., 102:131, 1969.PubMedGoogle Scholar
  12. 12.
    Bliznakov, E., A. C. Casey and E. Premuzic, Experientia, 26: 953, 1970.PubMedCrossRefGoogle Scholar
  13. 13.
    Schellenberg, K. A. and G. R. Coatney, Biochem. Pharm., 6:143, 1960.CrossRefGoogle Scholar
  14. 14.
    Harel, S. B., Am. J. Hyg., 3:652, 1923.Google Scholar
  15. 15.
    Cannon, P. and W. H. Taliaferro, J. Prev. Med., 5:37, 1931.Google Scholar
  16. 16.
    Knuttgen, H. J., Ann. Soc. Belge Med. Trop., 4:615, 1963.Google Scholar
  17. 17.
    Trubowitz, S. and B. Masek, Science, 162:273, 1968.PubMedCrossRefGoogle Scholar
  18. 18.
    Zuckerman, A., Exp. Parasitol., 15:138, 1964.PubMedCrossRefGoogle Scholar
  19. 19.
    Targett, G. A. T. and A. Voller, British Med. J., 2:1104, 1965.CrossRefGoogle Scholar
  20. 20.
    Bruce-Chwatt, L. J. and F. D. Gibson, Trans. Roy. Soc. Trop. Med. Hyg., 50:47, 1956.PubMedCrossRefGoogle Scholar
  21. 21.
    McGregor, I. A., S. Carrington and S. Cohen, Trans. Roy. Soc. Trop. Med. Hyg., 57:170, 1963.CrossRefGoogle Scholar
  22. 22.
    Roberts, J. A. and P. Tracey-Patte, J. Protozool., 16:728, 1969.PubMedGoogle Scholar
  23. 23.
    Cohen, S., G. A. Butcher and R. B. Crandall, Nature, 223:368, 1969.PubMedCrossRefGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Emile G. Bliznakov
    • 1
  1. 1.New England InstituteRidgefieldUSA

Personalised recommendations