Suppression of Second Set Reaction in Transplantation Immunity by Pretreatment with Histone of Graft Recipients and Donors
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Pretreatment of allograft recipients with histones extracted from cell nuclei results in prolongation of allograft survival time (1). A similar immunodepressive effect of histone has been demonstrated for humoral antibody response (2) and for sensitization using anaphylactic and tuberculin type reactions as experimental models (3). These findings are consistent with the observation that histones inhibit DNA dependent RNA-synthesis in cell-free systems (4,5). Furthermore, it was found that allograft rejection was also delayed when only the graft donors were treated with histone (6). These results were interpreted to suggest that histone prevents the transplanted cell to some degree from being recognized as antigen (“not self”) by the homologous graft recipient.
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