Antimacrophage Serum: Its Effect on the Immunological Competence and Lymphoid Tissues of the Rat

  • S. Knudson
  • M. R. Schwarz
  • W. B. Perkins
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)


While macrophages are thought to play a role in immune responses, their precise function has not been clearly defined. It has been suggested that macrophages “trap” antigens during the primary response, process the ingested material (1) and communicate “immunological information” to lymphocytes which initiate antibody formation (2). Macrophages may also destroy target cells, suggesting they have a role in the efferent as well as the afferent arm of the immune response (3). Since antisera raised against macrophages may further delineate the role of the cells in the immune response, this study was undertaken to determine the effects of antimacrophage serum (AMS) on lymphoid tissues and to compare these effects and the effect of AMS on cellular immunological competence with those observed after antilymphocytic serum treatment.


Lymphoid Tissue Kupffer Cell Thoracic Duct Mixed Lymphocyte Reaction Normal Rabbit Serum 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • S. Knudson
    • 1
  • M. R. Schwarz
    • 1
  • W. B. Perkins
    • 1
  1. 1.Department of Biological Structure, School of MedicineUniversity of WashingtonSeattleUSA

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