Cytochemistry of Lysosomes of the Liver RES during Malaria Infection at the Electronmicroscopic Level

  • P. H. K. Jap
  • C. Jerusalem
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)


Malarial infection (Plasmodium berghei) in mice can be regarded as a model for studying drastic RES changes. We used the liver as one of the organs which undergoes very severe changes, due both to the parasitic agent and to its toxin. These structural alterations are the result of the effect of the toxicity combined vith the administered infection dose (1).


Acid Phosphatase Esterase Activity Acid Phosphatase Activity Malarial Infection PLasmodium Berghei 
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  1. 1.
    Sengers, R.C.A., P.L. Liem, W.H. Doesburg, Exp. Parasit., in press, 1970.Google Scholar
  2. 2.
    Aikawa, M., T. Antonovych, J. Parasit., 50:620, 1964.PubMedCrossRefGoogle Scholar
  3. 3.
    Kretschmar, W., C. Jerusalem, Z. Tropenmed. Parasit. 14:279, 1963.Google Scholar
  4. 4.
    Jervis, H.R., D.K. MacCallum, H. Sprinz, Arch. Path., 86:328, 1968.PubMedGoogle Scholar
  5. 5.
    MacCallum, D.K., J. Reticuloendothel., Soc, 6:232, 1969.Google Scholar
  6. 6.
    Sherman, I.W., J.B. Mudd, W. Trager, Nature 208:691, 1965.PubMedCrossRefGoogle Scholar
  7. 7.
    Sabatini, D.D., K. Bensch, R.J. Barrnett, J. Cell. Biol. 17:19, 1963.PubMedCrossRefGoogle Scholar
  8. 8.
    Seligman, A.M., M.J. Karnovsky, H.L. Wasserkrug, J.S. Hanker, J. Cell Biol. 38:1, 1968.PubMedCrossRefGoogle Scholar
  9. 9.
    Smith, R.E., M.G. Farquhar, Sci. Instrum. News 10:13, 1965.Google Scholar
  10. 10.
    Gomori, G., Arch. Path. 32:189, 1941.Google Scholar
  11. 11.
    Barka, T., P.J. Anderson., J. Histochem. Cytochem. 10:741, 1962.CrossRefGoogle Scholar
  12. 12.
    Goldfischer, S., J. Histochem. Cytochem., 13:520, 1965.PubMedCrossRefGoogle Scholar
  13. 13.
    Wachstein, M., C. Falcon., J. Histochem. Cytochem., 9:325, 1961.PubMedCrossRefGoogle Scholar
  14. 14.
    Barka, T., J. Histochem. Cytochem., 12:229, 1964.PubMedCrossRefGoogle Scholar
  15. 15.
    Hopsu-Havu, V.K., A.U. Arstila, H.J. Helminen, H.O. Kalimi, G.G. Glenner, Histochemie 8:54, 1967.PubMedGoogle Scholar
  16. 16.
    Miller, F. Beitr. Path. Anat., 130:253, 1964.Google Scholar
  17. 17.
    Hugon, J., M. Borgers; J. Cell Biol. 33, 212, 1967.PubMedCrossRefGoogle Scholar
  18. 18.
    Jap, P., C. Jerusalem, Acta Histochem. (Jena), Suppl.-Bd. 10 in press, 1970.Google Scholar
  19. 19.
    Jerusalem, C., U. Heinen. Z. Tropenmed. Parasit. 16:377, 1965.Google Scholar
  20. 20.
    Aikawa, M. C. G. Huff, H. Sprinz. Milit. Med. 131:969, 1966.Google Scholar
  21. 21.
    Rudzinska, M.A. Int. Rev. Cytol. 25:161, 1969.PubMedCrossRefGoogle Scholar
  22. 22.
    Straus, W. J., Histochem. Cytochem. 12,470, 1964a.CrossRefGoogle Scholar
  23. Straus, W. J., J. Cell Biol. 20, 497, 1964b.PubMedCrossRefGoogle Scholar
  24. Straus, W. J., J. Cell Biol. 21,295, 1964c.PubMedCrossRefGoogle Scholar
  25. 23.
    Roy, A.B. Advances Enzym., 22:205, 1960.Google Scholar
  26. 24.
    Spencer, B., Biochem. J., 69:155, 1958.PubMedGoogle Scholar

Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • P. H. K. Jap
    • 1
  • C. Jerusalem
    • 1
  1. 1.Laboratory of Cyto-HistologyUniversity of NijmegenThe Netherlands

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