Fate of Streptococcal Antigens in the Reticuloendothelial System of the Mouse Liver
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Because of the clinical and epidemiological evidence that group A streptococci play a major role in the pathogenesis of rheumatic fever and glomerulonephritis and the belief that these may be immunologic diseases (1), a number of investigations have centered on the in vivo distribution of or the host immunologic response to various components of these organisms after injection into experimental animals or natural infection. Studies of M protein, A and A variant cell wall carbohydrates, mucopeptide, cell membrane and cytoplasmic antigens have been made (2–6). However, there is only limited information on the degradation in vivo of whole group A streptococci after intravenous injection (7) and especially of the role of the reticuloendothelial system (RES) in this process.
KeywordsKupffer Cell Rheumatic Fever Reticuloendothelial System Reticulin Fiber Streptococcal Cell Wall
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