Possible Participation of Serum-Complement in the Intracellular Killing of E. Coli

  • Jörg Menzel
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 15)


Complement (c) was detected in 1889 by its bactericidal activity against gram-negative bacteria (1). In 1903 (2), it was discovered that C also had an opsonizing effect on bacteria, even if they were resistant to the bactericidal activity. Optimal opsonization was obtained when the third component of C was activated and attached to the bacterial surface (3) whereas for the bactericidal activity all nine components were required (4,5,6).


Bactericidal Activity Cover Slip Viable Bacterium Bacterial Surface Intracellular Killing 
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Copyright information

© Plenum Press, New York 1971

Authors and Affiliations

  • Jörg Menzel
    • 1
  1. 1.DFG-Forschungsgruppe RotherMax-Planck-Institut für ImmunbiologieFreiburgGermany

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