The Temporary Sequestration of C3-Coated Red Cells (EC43) in the RES of the Rabbit: A Mechanism for the Non-Lytic Damage of Red Cells by Complement
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The removal of inert particulate material or opsonized bacteria and red cells from the circulation at sites in the RES is normally a permanent and irreversible event (l, 2, 3, 4). However, red cells which have fixed complement without proceeding to lysis may be an exception to this rule and complement-coated red cells can under certain conditions undergo only temporary sequestration in the RES. The present report describes a possible mechanism for this temporary sequestration; a mechanism which causes damage to the red cell without lysis and is related to the activity of membrane-bound C3, the third component of complement.
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