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Extrinsic Versus Intrinsic, Coagulation-Fibrinolysis: In the Pathophysiology of Shock and Exsanguinating Diatheses

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Shock: Biochemical, Pharmacological, and Clinical Aspects

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 9))

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Abstract

Disseminated intravascular coagulation (DIC) can cause circulatory failure and/or depletion of hemostasis. “Reactive” fibrinolysis removes fibrin from vital circulations, occlusions, of which otherwise could be fatal. Inhibitors released during the fibrinolysis (the ICF, or intravascular coagulation-fibrinolysis) can cause anticoagulation, adequate in itself to cause total incoagulability and exsanguinating hemorrhagic diathesis. DICs without, or with lysis (ICF), can be initiated in diverse ways and conditions.

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Authors and Affiliations

  1. Obstetrics & Gynecology Wayne County General Hospital, University of Michigan, Eloise, Michigan, 48132, USA

    Charles L. Schneider Ph.D., M.D.

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  1. Charles L. Schneider Ph.D., M.D.
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Editors and Affiliations

  1. Institute of Pharmacology, University of Milan, Milan, Italy

    Aldo Bertelli

  2. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1970 Plenum Press, New York

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Schneider, C.L. (1970). Extrinsic Versus Intrinsic, Coagulation-Fibrinolysis: In the Pathophysiology of Shock and Exsanguinating Diatheses. In: Bertelli, A., Back, N. (eds) Shock: Biochemical, Pharmacological, and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3201-5_5

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  • DOI: https://doi.org/10.1007/978-1-4684-3201-5_5

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