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Shock: Biochemical, Pharmacological, and Clinical Aspects pp 171–187Cite as

Several Pharmacologic and Biochemical Aspects of Cysteamine- and Cystamine-Induced Shock

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 9))

Abstract

Cysteamine [HSCH2CH2NH2] and cyst amine [(H2NCH2 CH2)2S2]provide remarkable protection against the action of ionizing radiation (1, 2). Numerous attempts to explain, the mode of action, of these substances followed the initial discovery of their radioprotective effects by Bacq and coworkers in 1951 (3). The present study was undertaken in order to elucidate the cardiovascular properties of these radioprotectors. A clearer understanding of their effect on oxygen, distribution at the cellular level seemed desirable, since anoxia is known to provoke marked biochemical changes which enhance cellular radioresistance.

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Author information

Authors and Affiliations

  1. Laboratory of Radiobiology, Léon Fredericq Institute and Laboratory of Physiopathology, University of Liège, Belgium

    P. van Caneghem, J. Lecomte, Z. M. Bacq & M. L. Beaumariage

Authors
  1. P. van Caneghem
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  2. J. Lecomte
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  3. Z. M. Bacq
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  4. M. L. Beaumariage
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Editor information

Editors and Affiliations

  1. Institute of Pharmacology, University of Milan, Milan, Italy

    Aldo Bertelli

  2. Department of Biochemical Pharmacology, School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1970 Plenum Press, New York

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van Caneghem, P., Lecomte, J., Bacq, Z.M., Beaumariage, M.L. (1970). Several Pharmacologic and Biochemical Aspects of Cysteamine- and Cystamine-Induced Shock. In: Bertelli, A., Back, N. (eds) Shock: Biochemical, Pharmacological, and Clinical Aspects. Advances in Experimental Medicine and Biology, vol 9. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3201-5_13

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  • DOI: https://doi.org/10.1007/978-1-4684-3201-5_13

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3203-9

  • Online ISBN: 978-1-4684-3201-5

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