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Activation of Central Pain Pathways by Bradykinin and the Effect of Analgesics

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Bradykinin and Related Kinins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 8))

Abstract

Earlier studies have demonstrated that the administration of brady-kinin IA or IP elicits a constellation of behavioral and autonomic responses typical of pain in unrestrained dogs and cats as well as verbal reports of pain in man (4). The present observations concern the effect of brady-kinin and some analgesics on the activity of neurons in regions known as central pain pathways.

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References

  1. Feltz, P., Krauthamer, G. and Albe-Fessard, D. Neurons of the medial diencephalon. I. Somatosensory responses and caudate inhibition. J. Neurophysiol. 30, 55–80, (1967).

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  2. Hirata, M., Tanaka, S., Taira, N., Hashimoto, K. Comparative studies on pseudaffective responses to different algesic substances in conscious dogs. The effect of sodium salicylate. Arch. Int. Pharmacodyn. 162, 150–161, (1966).

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  3. Krauthamer, G., Feltz, P. and Albe-Fessard, D. Neurons of the medial diencephalon. II. Excitation of central origin. J. Neuro-physiol. 30, 81–97, (1967).

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  4. Lim, R.K.S. Neuropharmacology of pain and analgesia. In 3rd. Int. Pharmacol. Meet., Vol. 9, M. Rocha e Silva (ed.). Pergamon Press, Oxford, 1966.

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  5. Lim, R. K. S., Guzman, F., Rodgers, D. W., Goto, K., Braun, C., Dickerson, G. D., Engle, R.J. Site of action of narcotic and nonnarcotic analgesics determined by blocking bradykinin-evoked visceral pain. Arch. Int. Pharmacodyn., 152, 25–58(1964).

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  6. Lim, R. K. S., Liu, C. N., Guzman, F., Braun, C. Visceral receptors concerned in visceral pain and the pseudoaffective response to intra-arte rial injection of bradykinin and other algesic agents. J. Comp. Neurol., 118, 269–294(1962).

    Article  PubMed  CAS  Google Scholar 

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Author information

Authors and Affiliations

  1. Dept. Physiology, College of Physicians & Surgeons Columbia Univ., New York, USA

    G. Krauthamer

  2. Medical Sciences Research Laboratory, Miles Laboratories, Inc., Elkhart, Ind., USA

    R. K. S. Lim, F. Guzman & R. R. Fulp

Authors
  1. G. Krauthamer
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  2. R. K. S. Lim
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  3. F. Guzman
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  4. R. R. Fulp
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Editor information

Editors and Affiliations

  1. Department of Clinical Pharmacology, University of Florence, Florence, Italy

    F. Sicuteri

  2. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, U.S.P., Sao Paulo, Brazil

    M. Rocha e Silva

  3. Department of Biochemical Pharmacology School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1970 Plenum Press, New York

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Krauthamer, G., Lim, R.K.S., Guzman, F., Fulp, R.R. (1970). Activation of Central Pain Pathways by Bradykinin and the Effect of Analgesics. In: Sicuteri, F., e Silva, M.R., Back, N. (eds) Bradykinin and Related Kinins. Advances in Experimental Medicine and Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3198-8_66

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  • DOI: https://doi.org/10.1007/978-1-4684-3198-8_66

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3200-8

  • Online ISBN: 978-1-4684-3198-8

  • eBook Packages: Springer Book Archive

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