Abstract
Considerable effort is being spent in our laboratory, to collect some direct evidences of participation of the kinin system in some models of the acute inflammatory reaction. In this work we have the collaboration of many colleagues (2), who should be considered co-workers of this review. Some of them are attending this Symposium and will present their own papers. My task is to present in a condensed form the many evidences we have now of the participation of kinins in the swelling produced in the rat’s paw by moderate heat (45°C), sulfated polymers, such as cellulose sulphate, SN-263, polyvinyl sulfate, polyethylene sulfate, as well as that produced by the well know inflammatogens, carragenin and dextran sulfate. In previous reviews, we have adduced evidences in favor of the participation of the kinin system in shocks produced by prteases, such as trypsin, pronase and nagarse (Rocha e Silva, 1969; Rocha e Silva et al., 1967, 69b).
Aided in part by Research Grant HE1 0074-03 from the U. S. -P. H. S., National Institutes of Health.
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Armstrong, D., Mills, G. L. and Stewart, J. W.: Thermally induced effects on the kinin-forming system of native human plasma, 37°–0°C and 37°–50°C. In: Intern. Symp. on Vasoactive Polypeptides: Bradykinin and Related Kinins (M. Rocha e Silva and Hanna A. Rothschild, Edit.), Edart, Sao Paulo, p. 167, 1967.
Camargo, A. C. M. and Graeff, F. G.: Subcellular distribution and properties of the bradykinih inactivation system in rabbit brain homogenates. Biochem. Pharmacol. 18: 548, 1969.
Collier, H. O. J.: Some pharmacological correlates of antiinflammatory activity: a study of nonsteroidal anti-inflammatory drugs as antagonists of local hormones. In: Intern. Symp. on Non-steroidal and Anti-inflammatory Drugs. (Milan, 1964). Excerpta Med. Intern. Congr. Ser. 82: 139, 1965.
Collier, H. O. J., Holgate, J. A., Schachter, M., and Shorley, P. G.: The bronchoconstrictor action of bradykinin in the guinea pig. Brit. J. Pharmacol.15: 290, 1960.
Ferreira, S. H. and Rocha e Silva, M.: Liberation of bradykinin in the circulating blood of dogs by trypsin, chymotryp-sin and nagarse. Brit. J. Pharmacol.36 (in press), 1969.
Ferreira, S. H. and Vane, J. R.: The detection and estimation of bradykinin in the circulating blood. Brit. J. Pharmacol.29.: 267, 1967.
Fox, R. H. and Hilton, S. M.: Bradykinin formation in human skin as a factor in heat vasodilation. J. Physiol.142: 219, 1958.
Garcia Lerne, J.; Schapoval, E.S.; and Rocha e Silva, M.: Factors influencing local edema in the rat’s paw produced by macromolecular agents (dextran, carragenin and cellulose-sulfate). Abstr. III Intern. Pharmacol. Congr. (São Paulo), no. 392, 1966.
Garcia Lerne, J.; Schapoval, E. S.; and Rocha e Silva, M.: Factors influencing the development of local swelling induced in the rat’s paw by macromolecular compounds and heating. In:Intern. Symp. on Vaso-active Polypeptides: Bradykinin and Related Kinins (M. Rocha e Silva and Hanna A. Rothschild, Edit.), Edart, Sao Paulo, p. 213, 1967.
Gilfoil, T. M. and Klavins, I.: 5-Hydroxytryptamine bradykinin and histamine as mediators of inflammatory hyperesthesia. Am. J. Physiol., 208: 867, 1965.
Hamberg, U. and Rocha e Silva, M.: On the release of bradykinin by trypsin and snake venom. Arch. Intern. Pharmacodyn., 110: 222, 1957.
Hilton, S. M. and Lewis, G. P.: Functional vasodilatation in the submandibular salivary gland. Brit. Med. Bull., 13: 189, 1957.
Lewis, G. P.: Plasma kinins and other vaso-active compounds in acute inflammation. Ann. N. Y. Acad. Sci., 116: 874, 1964.
Lim, R. K. S., Guzman, F., Rodgers, D. W., Gotto, K., Braun, C., Dickerson, G. D., and Engle, R. J.: Site of action of narcotic and non-narcotic analgesics determined by blocking bradykinin evoked visceral pain. Arch. Intern. Pharmacodyn., 152: 25, 1964.
Reis, M. L.: Liberacao de cininas por enzimas proteoliticas. Thesis, School of Pharmacy, Ribeirão Prêto, São Paulo, Brazil, 1969.
Rocha e Silva, M.: Pharmacological action of proteases. Ann. N. Y. Acad. Sci.146: 448, 1968.
Rocha e Silva, M.: Chemical mediators. In: Proc. IV Congr. Panam. Reumatol (Mexico, 1967). Excerpta Med. Intern. Congr. Ser. 165: 17, 1969.
Rocha e Silva, M. and Antonio, A.: Release of bradykinin and the mechanism of production of a “thermic edema (45° C)” in the rats paw. Med. Exptl.3: 371, 1960.
Rocha e Silva, M.; Cavalcanti, R. Q.; and Reis, M. L.: Anti-inflammatory action of sulfated polysaccharides. Biochem. Pharmacol.18: 1285, 1969(a).
Rocha e Silva, M.; Garcia Lerne, T.,; and Souza, J. M. de: The significance of the kinin-system in inflammatory reactions. In: Intern. Symp. on Inflammation, Biochemistry and Drug In-teraction(Como, 1968). Excerpta Med. Intern. Congr. Ser. (in press), 1969(b).
Rocha e Silva, M.; Reis, M. L.; and Ferreira, S. H.: Release of kinins from fresh plasma under varying experimental conditions. Biochem. Pharmacol.16: 1665, 1967.
Vane, J. R.: The use of isolated organs for detecting active substances in the circulating blood. Brit. J. Pharmacol.23: 360, 1964.
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e Silva, M.R. (1970). Direct Evidence on the Participation of Bradykinin and Related Kinins in Acute Inflammatory Reactions. In: Sicuteri, F., e Silva, M.R., Back, N. (eds) Bradykinin and Related Kinins. Advances in Experimental Medicine and Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3198-8_62
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