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Interference of Carrageenin, Non-Steroidal Anti-Inflammatory Drugs and Protease Inhibitors with the Kallikrein-Kinin System

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Bradykinin and Related Kinins

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 8))

Abstract

Carrageenin has kininogen depleting properties in the rat (1). Its local oedema inducing effects are inhibited by phenylbutazone and other non-steroidal antiinflammatory drugs. The kaolin induced elevation of kinin activity in the rat oedema fluid is also counteracted by phenylbutazone, while this drug is unable to inhibit the polyvinylpyrrolidone induced oedema, where a lack of increased kinin activity was demonstrated (2). In the present work additional support is given to the postulation that the antiinflammatory action of phenylbutazone may partly be due to its interference with the kallikrein-kinin system.

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References

  1. ROTHSCHILD, A.M., International Symposium on Vaso-active Polypeptides, Bradykinin and related Kinins (Eds. Rocha e Silva, M, and Rothschild, H.A.) P. 197, Edart, São Paulo, 1967.

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  2. BONTA, I.L., and de VOS, C.J., European J. Pharmacol., 1, 222, 1967.

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  4. BHARGAVA, N., BONTA, I.L., (to be published).

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  5. LECOMTE, J., Comp. Rend. Soc. Biol., 162, 807, 1968.

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  6. FREY, E.K., KRAUT, H., and WERLE, E., “Das kallikrein-kinin-system und seine inhibitoren” Ferdinand enke Verlag, Stuttgart, P. 57–58, 1968.

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  7. NARTICOVA, V.F., and PASKHINA, T.S., Biokhimiya, 34, 282, 1969.

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Authors and Affiliations

  1. Departments of Pharmacology, S.A. Organon, Eragny-sur-Epte, France

    B. B. Vargaftig, N. Bhargava, C. J. de Vos & I. L. Bonta

  2. N.V. Organon, Oss, The Netherlands

    B. B. Vargaftig, N. Bhargava, C. J. de Vos & I. L. Bonta

Authors
  1. B. B. Vargaftig
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  2. N. Bhargava
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  3. C. J. de Vos
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  4. I. L. Bonta
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Editor information

Editors and Affiliations

  1. Department of Clinical Pharmacology, University of Florence, Florence, Italy

    F. Sicuteri

  2. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, U.S.P., Sao Paulo, Brazil

    M. Rocha e Silva

  3. Department of Biochemical Pharmacology School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1970 Plenum Press, New York

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Vargaftig, B.B., Bhargava, N., de Vos, C.J., Bonta, I.L. (1970). Interference of Carrageenin, Non-Steroidal Anti-Inflammatory Drugs and Protease Inhibitors with the Kallikrein-Kinin System. In: Sicuteri, F., e Silva, M.R., Back, N. (eds) Bradykinin and Related Kinins. Advances in Experimental Medicine and Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3198-8_58

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  • DOI: https://doi.org/10.1007/978-1-4684-3198-8_58

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3200-8

  • Online ISBN: 978-1-4684-3198-8

  • eBook Packages: Springer Book Archive

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