Activation of the Plasma Kallikrein System During Myocardial Ischemia

  • Bertram Pitt
  • John Mason
  • C. Richard Conti
  • Robert W. Colman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


Sicuteri (1) and a number of other investigators have postulated that the kallikrein system may play a role in the hemodynamic response to myocardial ischemia and may be responsible for the associated anginal pain. This hypothesis is based upon the observation that bradykinin has been shown to be a potent coronary vasodilator (2) and in addition is known to cause pain (3).


Myocardial Ischemia Coronary Sinus Atrial Pace Acetyl Lysine Plasma Kallikrein 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Bertram Pitt
    • 1
  • John Mason
    • 1
  • C. Richard Conti
    • 1
  • Robert W. Colman
    • 1
  1. 1.Johns Hopkins University School of Medicine and Harvard Medical SchoolUSA

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