Eledoisin and Fibrinolysis in Man

Abstract

We injected eledoisin into the humeral artery and determined the fibrinolytic activity of the returning venous blood in the same limb. In two groups of 10 subjects, clinically healthy from the vascular point of view, we proceeded on different days to carry out two series of tests, as follows:

• 1. Rapid administration (5 seconds) of 2 μg of eledoisin into the humeral artery, and determination of the fibrinolytic activity and the rate of the proactivator in the returning venous blood of this limb, both before and after the injection.

• 2. Slow intravenous administration of 2 μg of eledoisin and determination of the fibrinolytic activity of the venous blood before and after the injection.

• 3. Slow intra-arterial administration of eledoisin in the dose of 2. 5 μg per minute for a space of 20 minutes and determination of the fibrinolytic activity in the returning venous blood and the quantity of the proactivator before and during the injection.

• 4. Addition of eledoisin in different doses (0. 5, 1, 1. 5, 2 μg) in samples of blood (4 ml.) and study of the haematic fibrinolytic activity “in vitro”.