Local Ischemia as a Kininogen Depressant: Effect of Cortisone, Taurine and a Kallikrein Inhibitor

  • A. Bavazzano
  • N. Sidell
  • S. Michelacci
  • F. Sicuteri
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


Some years ago this group suggested that microvascular endothelium may be considered as one of the regulators of kinin metabolism on the basis of the following data:
  1. a)

    Arterial kininogen is slightly higher than that of venous (15).

  2. b)

    Venous recovery of intraarterial bradykinin is very poor, indicating a high capillary clearance (1, 2).

  3. c)

    During the reactive hyperemia following circulatory arrest, kininogen decreases (15).



Ischemic Limb Circulatory Arrest Intermittent Claudication Reactive Hyperemia Microvascular Endothelium 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1).
    ALLWOOD M.J. and 4 G.P.: J. Physiol.(Loncl.) 166, 47 (1963)Google Scholar
  2. 2).
    ALLWOOD M.J. and LEWIS G.P.: J. Physiol. (Lond.) 170, 571 (1964)Google Scholar
  3. 3).
    ARMSTRONG D. and MILLS G.L.: J. Physiol (Lond.) 179, 890 (1965)Google Scholar
  4. 4).
    ARMSTRONG D., MILLS G.L. and SICUTERI F.: In Hypotensive Peptides — Springer Verlag N.Y. Pub. Erdos, Back, Sicuteri Eds., 139 (1966)CrossRefGoogle Scholar
  5. 5).
    BECATTINI U.: Sett. Med. 55, 1355 (1967)Google Scholar
  6. 6).
    CUSCHIERI A., Onabanjo A.O. and James P.B.: In the present bookGoogle Scholar
  7. 7).
    DINIZ C.R., CARVALHO L.F., RYAN J. and ROCHA E SILVA M.: Nature 192, 1194 (1961)PubMedCrossRefGoogle Scholar
  8. 8).
    EDERY H. and LEWIS G.P.: Proc. Physiol. Soc. J. Physiol. 160, 20, 1961Google Scholar
  9. 9).
    EISEN V., GREENBAUM L. and LEWIS G.P.: Brit. J. of Pharmac. 34, 169 (1968)Google Scholar
  10. 10).
    GUIDOTTI A., BUFFONI F. and GIOTTI A.: Boll. Soc. Ital. Biol. Sper. 43, 1390(1967)Google Scholar
  11. 11).
    SCHARNAGEL K. and GREEF K.: Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 253 81 (1967)Google Scholar
  12. 12).
    SICUTERI F., FRANCHI G., FANCIULLACCI M., DEL BIANCO P.L. and SIDELL N.: In “Pharmacology of Hormonal Polypeptides and Proteins”, Plenum Press 601 (1968)Google Scholar
  13. 13).
    SICUTERI F., FRANCHI G., FANCIULLACCI M., GIOTTI A. and GUIDOTTI A.: Clin. Terap. 49, 205 (1969)Google Scholar
  14. 14).
    SICUTERI F., PERITI P., FANCIULLACCI M. and SANTINI D.: Boll. Soc. Ital. Biol. Sper. 40, 955 (1964)Google Scholar
  15. 15).
    SICUTERI F., PERITI P., FRANCHI G. and SANTINI D.: Boll. Soc. Ital. Biol. Sper. 39, 310 (1963)PubMedGoogle Scholar
  16. 16).
    WELTY J.D. JR. and READ W.O.: J. Pharmac. Exp. Ther. 144, 110 (1964)Google Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • A. Bavazzano
    • 1
  • N. Sidell
    • 1
  • S. Michelacci
    • 1
  • F. Sicuteri
    • 1
  1. 1.Department of MedicineUniversity of FlorenceFlorenceItaly

Personalised recommendations