New Vasoactive Polypeptides Isolated from Ox Alfa-2 Macroglobulin
In our previous investigations. /1/, a carbohydrate containing alfa-2 microglobulin isolated from bovine plasma with molecular weight of a few hundred thousand, has been found to induce smooth muscle contraction when tested on isolated guinea-pig ileum and on rat uterus. This protein fraction exhibited also a potentiating effect on both guinea-pig ileum and on rat uterus in case either histamine or bradykinin was used as standard. In addition to these stimulant effects, it relaxes the rat duodenum.
KeywordsSmooth Muscle Contracting Trypsin Action Peptide Peak Bovine Plasma Peptide Component
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- Gecse, Á., E.Zsilinszky, A.Lózsa, S.Karády: J.Pharm. Pharmacol. In press.Google Scholar