Depletion of Kininogen I by Stem Bromelain and Its Significance Prevention of Adrenalin-Induced Pulmonary Edema in Rats

  • Makoto Katori
  • Satoru Mineshita
  • Tatsuro Shigei
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


It was found in this laboratory that an intravenous injection of stem bromelain (BRM) prevented the adrenaline-induced pulmonary edema in rats, while an injection of papain (PAP) did not, in spite of the fact that both enzymes are thiol-proteases from the plant origin (Shigei et al., 1967). In addition, the preventive effect of BRM was due to the proteolytic activity of the enzyme, because both the caseinolytic and the edema-preventing activities were abolished after incubation of the enzyme with a SH inhibitor, N-ethyl-maleimide (Enomoto et al., 1968).


Pulmonary Edema Incubation Mixture Organ Bath Plasma Kallikrein Kinin System 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Makoto Katori
    • 1
  • Satoru Mineshita
    • 1
  • Tatsuro Shigei
    • 1
  1. 1.Department of Pharmacology, Institute for Cardiovascular DiseasesTokyo Medical and Dental UniversityJapan

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