An Electron Microscopic Study of the Vascular Endothelium as a Site for Bradykinin and Adenosine-5′-Triphosphate Inactivation in Rat Lung

  • Una Smith
  • James W. Ryan
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


Bradykinin is inactivated in one circulation through the intact or “blood-free rat lung (1). Inactivation of bradykinin occurs by hydrolysis of peptide bonds, yet the effluent of a blood-free lung preparation does not contain sufficient hydrolase activity to account for this extremely rapid and efficient degradation. Furthermore, there is no measurable retention of bradykinin or its peptide fragments by the lung. It seems likely, therefore, that bradykinin is inactivated by cellular enzymes at or near the endothelium of pulmonary blood vessels.


Capillary Endothelial Cell Multivesicular Body Capillary Endothelium Capillary Lumen Pinocytotic Vesicle 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.


  1. 1.
    Ryan, James W., Juan Roblero and John Morrow Stewart. Biochem. J. 110:795–797, 1968.Google Scholar
  2. 2.
    Marchesi, V. T. and R. J. Barrnett. J. Cell Biol. 17:547, 1965.CrossRefGoogle Scholar
  3. 3.
    Tice, Lois W. and David S. Smith. J. Cell Biol. 25:121–135, 1965.CrossRefGoogle Scholar
  4. 4.
    Tice, L. W. Tissue & Cell 1:97–101, 1969.CrossRefGoogle Scholar
  5. 5.
    Reynolds, E. A. J. Cell Biol. 12:208–212, 1963.CrossRefGoogle Scholar
  6. 6.
    Wachstein, Max and Elizabeth Meisel. Am. J. Clin. Path. 22:13–23, 1957.Google Scholar
  7. 7.
    De Duve, C. and R. Wattiaux. Ann. Rev. Physiol. 28:435–492, 1966.CrossRefGoogle Scholar
  8. 8.
    Locke, M. and J. V. Collins. J. Cell Biol. 36:453–483, 1968.CrossRefPubMedGoogle Scholar
  9. 9.
    Smith, D. S., K. Compher, M. Janners, C. Lipton and L. W. Wittle. J. Morph. 127:41–72, 1969.CrossRefGoogle Scholar
  10. 10.
    Binet, L. and M. Burstein. Presse Medicale 58:1201, 1950.PubMedGoogle Scholar
  11. 11.
    Palade, G. E. Anat. Record 130:467, 1958.Google Scholar
  12. 12.
    Palade, G. E. and R. R. Bruns. J. Cell Biol. 37:633–649, 1968.CrossRefPubMedGoogle Scholar
  13. 13.
    Porter, K. R. and J. R. Sotelo. J. Biophys. Biochem. Cytol. 5:327–342, 1959.CrossRefPubMedGoogle Scholar
  14. 14.
    Cardell, R. R., S. Badenhausen and K. R. Porter. J. Cell Biol. 34:123–155, 1967.CrossRefPubMedGoogle Scholar
  15. 15.
    Cushman, D. W. and H. S. Cheung. Fed. Proc. 28:799, 1969, (abstract 3019).Google Scholar

Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Una Smith
    • 1
  • James W. Ryan
    • 1
  1. 1.Department of MedicineUniversity of Miami School of MedicineMiamiUSA

Personalised recommendations