Abstract
Mechanisms by which tumor vasculature develops and is maintained are under stood only limitedly. Factors affecting tumor vascular space and the regulation of blood flow through tumors have been described recently (1). The sequential development of the tumor vasculature also has been studied extensively (2, 3), and the subject of a recent review (4). Sarcomas transplanted into Algire chambers develop an exceedingly rich vascular pattern with capillary proliferation beginning three days post-transplant. These newly-formed vessels are of wide diameter with many arterial-venous anastamoses, resulting in reduced tumor blood flow.
Supported by United States Public Health Service grant #HE-11492, National Heart Institute.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Gullino, P.M. Progress Exper. Tumor Res. 8: 1, 1966.
Algire, G. H. and Chalkley, H. W.: J. Natl. Cancer Inst. 6: 73, 1945.
Algire, G. H.: J. Natl. Cancer Inst. 11: 555, 1950.
Urbach, F.: Natl. Cancer Inst. Monograph 10, 539, 1963.
Abrams, H. L.: Nature, 201: 167, 1964.
Cater, D. B., Petrie, A., and Watkinson, D. A.: Acta. Radiol 3: 109, 1965.
Cater, D.B. and Taylor, C.R.: Brit. J. Cancer, 20: 517, 1966.
Bierman, H. R., Kelly, K. H., and Singer, G.: J. Natl. Cancer Inst. 12: 701, 1952.
Oates, J. A., Pettinger, W. A., and Doctor, R. B.: J. Clin. Invest. 45: 173, 1966.
DiMattei, P.: Biochem. Pharmacol, 14: 1388, 1965.
Back, N., Tsukada, G. A., Castilone, B., and Aungst, C.W.: The Pharmacologist, 7: 151, 1965.
Back, N. and Steger, R.: Fed. Proc. 27: 96, 1968.
Back, N. and Steger, R.: Proc. Soe. Exper.Bio. & Med. In Press
Ide, A. G., Baker, N. H., and Warren, S. L.: Am. J. Roentgenol. Radiotherap. 42: 891, 1939.
Gullino, P.M., and Granthan, F. H.: J. Natl. Cancer Inst. 27: 1465, 1961.
Gardner, B., Dollinger, M., Silen, W., Back, N., and O’Reilly, S.: Surgery, 61: 846, 1967.
Cater, D.B., Adair, H. M., and Grove, C.A.: Acta. Radiol. 20: 504, 1966.
Back, N. and Steger, R.: Vasoactive regulators in tumor tissue. Pharmacol. Res. Commun. 1: 135, 1969 (Abstract).
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1970 Plenum Press, New York
About this chapter
Cite this chapter
Back, N., Steger, R. (1970). Characterization of Pre-Kallikrein Activity in Developing Transplanted Mammalian Tumors. In: Sicuteri, F., e Silva, M.R., Back, N. (eds) Bradykinin and Related Kinins. Advances in Experimental Medicine and Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3198-8_29
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3198-8_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3200-8
Online ISBN: 978-1-4684-3198-8
eBook Packages: Springer Book Archive