Characterization of Pre-Kallikrein Activity in Developing Transplanted Mammalian Tumors
Mechanisms by which tumor vasculature develops and is maintained are under stood only limitedly. Factors affecting tumor vascular space and the regulation of blood flow through tumors have been described recently (1). The sequential development of the tumor vasculature also has been studied extensively (2, 3), and the subject of a recent review (4). Sarcomas transplanted into Algire chambers develop an exceedingly rich vascular pattern with capillary proliferation beginning three days post-transplant. These newly-formed vessels are of wide diameter with many arterial-venous anastamoses, resulting in reduced tumor blood flow.
KeywordsTumor Blood Flow Tumor Extract Plasma Kallikrein Kallikrein Activity Epsilon Amino Caproic Acid
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- 1.Gullino, P.M. Progress Exper. Tumor Res. 8: 1, 1966.Google Scholar
- 2.Algire, G. H. and Chalkley, H. W.: J. Natl. Cancer Inst. 6: 73, 1945.Google Scholar
- 4.Urbach, F.: Natl. Cancer Inst. Monograph 10, 539, 1963.Google Scholar
- 6.Cater, D. B., Petrie, A., and Watkinson, D. A.: Acta. Radiol 3: 109, 1965.Google Scholar
- 10.DiMattei, P.: Biochem. Pharmacol, 14: 1388, 1965.Google Scholar
- 11.Back, N., Tsukada, G. A., Castilone, B., and Aungst, C.W.: The Pharmacologist, 7: 151, 1965.Google Scholar
- 13.Back, N. and Steger, R.: Proc. Soe. Exper.Bio. & Med. In PressGoogle Scholar
- 14.Ide, A. G., Baker, N. H., and Warren, S. L.: Am. J. Roentgenol. Radiotherap. 42: 891, 1939.Google Scholar
- 17.Cater, D.B., Adair, H. M., and Grove, C.A.: Acta. Radiol. 20: 504, 1966.Google Scholar
- 18.Back, N. and Steger, R.: Vasoactive regulators in tumor tissue. Pharmacol. Res. Commun. 1: 135, 1969 (Abstract).Google Scholar