An Analysis of Reserpine-Induced Hypersensitivity of Rabbit Aortic Strip to Eledoisin

  • I. Blašková
  • V. Kovalčík
  • R. Kvetňanský
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


The synthetic, bradykinin-like polypeptide eledoisin, which is known as a very potent hypotensive agent, contracts isolated vessels /Kovalčík,1963A The mechanism of the contractile effect of eledoisin on isolated vascular smooth muscle is not yet well understood. In our previous studies we found that after reserpine-pretreatment the maximal contraction of the rabbit isolated aorta to eledoisin is increased /Blašková et al., 1966/. Supersensitivity of isolated aorta from reserpine pretreated rabbit to eledoisin was also shown by Turker and Khairallah /1966/. It was suggested that the effect of eledoisin on isolated vascular smooth muscle is somehow dependent on catecholamine stores.


Vascular Smooth Muscle Monoamine Oxidase Inhibitor Maximal Contraction Rabbit Aorta Noradrenaline Content 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • I. Blašková
    • 1
  • V. Kovalčík
    • 1
  • R. Kvetňanský
    • 1
  1. 1.Department of PharmacologyKomensky University Medical SchoolBratislavaCzechoslovakia

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