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An Analysis of Reserpine-Induced Hypersensitivity of Rabbit Aortic Strip to Eledoisin

  • I. Blašková
  • V. Kovalčík
  • R. Kvetňanský
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)

Abstract

The synthetic, bradykinin-like polypeptide eledoisin, which is known as a very potent hypotensive agent, contracts isolated vessels /Kovalčík,1963A The mechanism of the contractile effect of eledoisin on isolated vascular smooth muscle is not yet well understood. In our previous studies we found that after reserpine-pretreatment the maximal contraction of the rabbit isolated aorta to eledoisin is increased /Blašková et al., 1966/. Supersensitivity of isolated aorta from reserpine pretreated rabbit to eledoisin was also shown by Turker and Khairallah /1966/. It was suggested that the effect of eledoisin on isolated vascular smooth muscle is somehow dependent on catecholamine stores.

Keywords

Vascular Smooth Muscle Monoamine Oxidase Inhibitor Maximal Contraction Rabbit Aorta Noradrenaline Content 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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References

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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • I. Blašková
    • 1
  • V. Kovalčík
    • 1
  • R. Kvetňanský
    • 1
  1. 1.Department of PharmacologyKomensky University Medical SchoolBratislavaCzechoslovakia

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