Modification of the Reactivity of Guinea-Pig Seminal Vesicles to Angiotensin and Tyramine by some Microsomal Enzyme Inducers
Previous reports have shown that neither angiotensin nor tyramine can stimulate the isolated guinea-pig seminal vesicles (Gascon and Walaszek, 1968; Gascon and Vaillancourt, 1969). However, both compounds are seen to induce a contraction of this isolated smooth muscle when they are applied after the addition of adrenaline. This effect is completely antagonized by phenoxybenzamine and a rapid tachyphylaxis develops, indicating an action via the release of endogenous catecholamine from extra-neuronal sites of storage. In another series of experiments, there was a marked increase in the reactivity of the isolated seminal vesicles to angiotensin and tyramine following pretreatment of guinea-pigs with testosterone and nandrolone (Gascon et al., 1969). Prior to 1956, the anabolic properties of androgens were thought to be restricted to secondary sexual tissues. During the past decade or so, data have been accumulating to indicate that the anabolic properties of androgens could also extend to non-sexual tissues. Axelrod, 1956, Quinn et al., 1958, Murphy and DuBois, 1958 and Booth and Gillette, 1962, among others have shown that various androgens exert potent anabolic effects upon drug metabolizing enzymes located in the microsomal fraction of mammalian liver.
KeywordsSeminal Vesicle Stimulant Effect Mammalian Liver Endogenous Catecholamine Pretreated Animal
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