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Bradykinin and Related Kinins pp 123–130Cite as

The Isolation and Partial Characterization of Kinin-Forming Enzymes and Other Active Components From Human Plasma

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 8))

Abstract

Three years ago in Ribeirão Prêto we presented evidence that antigen-antibody (Ag-Ab) precipitates can activate the kinin system if such precipitates are incubated with non-glass contacted guinea pig, rabbit or human serum. Such activated serum acquires the following properties: (a). It enhances vessel permeability when injected intradermally into guinea pigs pretreated with the antihistamine mepyramine. (b). It contracts the rat uterus; a reaction inhibited by carboxypeptidase-B, but not by serotonin antagonists. (c). It has TAME-esterase activity. (d). It enhances the clotting of recalcified plasma. (e). It causes hypotension when injected intravenously. Several serine esterase inhibitors suppress the permeability enhancing activity of Ag-Ab treated serum (6).

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References

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Author information

Authors and Affiliations

  1. Division of Experimental Pathology, University of Toronto, Toronto, Ontario, Canada

    Henry Z. Movat, Harold B. Sender, Mary P. Treloar & Yuko Takeuchi

Authors
  1. Henry Z. Movat
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  2. Harold B. Sender
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  3. Mary P. Treloar
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  4. Yuko Takeuchi
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Editor information

Editors and Affiliations

  1. Department of Clinical Pharmacology, University of Florence, Florence, Italy

    F. Sicuteri

  2. Department of Pharmacology, Faculty of Medicine of Ribeirao Preto, U.S.P., Sao Paulo, Brazil

    M. Rocha e Silva

  3. Department of Biochemical Pharmacology School of Pharmacy, State University of New York, Buffalo, New York, USA

    Nathan Back

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© 1970 Plenum Press, New York

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Movat, H.Z., Sender, H.B., Treloar, M.P., Takeuchi, Y. (1970). The Isolation and Partial Characterization of Kinin-Forming Enzymes and Other Active Components From Human Plasma. In: Sicuteri, F., e Silva, M.R., Back, N. (eds) Bradykinin and Related Kinins. Advances in Experimental Medicine and Biology, vol 8. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3198-8_16

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  • DOI: https://doi.org/10.1007/978-1-4684-3198-8_16

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3200-8

  • Online ISBN: 978-1-4684-3198-8

  • eBook Packages: Springer Book Archive

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