Bradykinin-Potentiating Peptides from the Venom of Bothrops Jararaca

  • Lewis J. Greene
  • John M. Stewart
  • Sergio H. Ferreira
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 8)


Bradykinin-potentiating factor (BPF) is a mixture of snake venom peptides which potentiate some of the pharmacological actions of bradykinin in vitro and in vivo (Ferreira, 1965; 1966). In this communication we describe the isolation of nine biologically active peptides from Bothrops jararaca venom, present the amino acid sequence determination of the smallest of the active peptides, PCA-Lys-Trp-Ala-Pro, and describe the synthesis of this peptide by the solid phase method.


Solid Phase Method Anhydrous Hydrogen Fluoride High Voltage Electrophoresis Amino Acid Sequence Determination Pyrrolidone Carboxylic 
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Copyright information

© Plenum Press, New York 1970

Authors and Affiliations

  • Lewis J. Greene
    • 1
  • John M. Stewart
    • 2
  • Sergio H. Ferreira
    • 3
  1. 1.Brookhaven Natl. Lab.UptonUSA
  2. 2.Univ. of Colorado Sch. of Med.DenverUSA
  3. 3.Faculty of Medicine of Ribeirão PrêtoRibeirão PrêtoBrazil

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