Skip to main content
SpringerLink
Log in

General Features of Metabolic Control as Applied to the Erythrocyte

  • Chapter
Book cover Red Cell Metabolism and Function

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 6))

Abstract

The purpose of this paper is to review the background and principles used to elucidate control mechanisms in multienzyme sequences. Examples are taken from the literature to illustrate the sites of control of erythrocyte glycolysis observed under different conditions, and the possible nature of the control chemicals. Emphasis will be placed on control of the 2,3-diphosphoglycerate (DPG) level in erythrocytes and possible feedback relationships between the concentration of free DPG, as determined by its differential binding to oxy- and deoxyhemoglobin, and the regulation of glycolysis. For a more extensive treatment of erythrocyte glycolysis, the reader is referred to several recent reviews (1–3).

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Rapoport, S., in P. N. Campbell and G. D. Greville (Editors), Essays in biochemistry, Vol. 4, Academic Press, New York, 1968, p. 69.

    Google Scholar 

  2. Murphy, J. R., J. Lab. Clin. Med., 55, 286 (1960).

    PubMed  CAS  Google Scholar 

  3. Yoshikawa, H., and Minakami, S., Folia Haemat., 89, 357 (1968).

    CAS  Google Scholar 

  4. De Verdier, C. H., Folia Haemat., 78, 184 (1962).

    Google Scholar 

  5. Tsutsui, E. A., Marks, P. A., and Reich, P., J. Biol. Chem., 237, 3009 (1962).

    PubMed  CAS  Google Scholar 

  6. Kauffman, F. C., Brown, J. G., Passonneau, J. V., and Lowry, O. H., J. Biol. Chem., 244, 3647 (1969).

    PubMed  CAS  Google Scholar 

  7. Rose, I. A., Warms, J. V. B., and O’Connell, E. L., Biochem. Biophys. Res. Commun., 15, 33 (1964).

    Article  PubMed  CAS  Google Scholar 

  8. Velick, S. F., and Furfine, C., in P. D. Boyer, H. Lardy, and K. Myrback (Editors). The enzymes, Vol. 7, Academic Press, New York, 1963, p. 243.

    Google Scholar 

  9. Rose, I. A., and Warms, J. V. B., J. Biol. Chem., 241, 4848 (1966).

    PubMed  CAS  Google Scholar 

  10. Chapman, R. G., Hennessey, M. A., Waltersdorph, A. M., Huennekens, F. M., and Gabrio, B. W., J. Clin. Invest., 41, 1249 (1962).

    Article  PubMed  CAS  Google Scholar 

  11. Pennell, R. B., in C. Bishop and D. M. Surgenor (Editors), The red blood cell, Academic Press, New York, 1964, p. 26.

    Google Scholar 

  12. Hess, B., in B. Wright (Editor), Control mechanisms in respiration and fermentation, Ronald Press Company, New York, 1963, p. 333.

    Google Scholar 

  13. Williamson, J. R., J. Biol. Chem., 240, 2308 (1965).

    PubMed  CAS  Google Scholar 

  14. Chance, B., and Williams, G. R., J. Biol. Chem., 217, 409 (1955).

    PubMed  CAS  Google Scholar 

  15. Chance, B., Williams, G. R., Holmes, W. F., and Higgins, J., J. Biol. Chem., 217, 439 (1955).

    PubMed  CAS  Google Scholar 

  16. Chance, B., Holmes, W. F., Higgins, J., and Connelly, C. M., Nature, 182, 1190 (1958).

    Article  PubMed  CAS  Google Scholar 

  17. Holmes, W. F., Trans. Farad. Soc., 55, 1122 (1959).

    Article  CAS  Google Scholar 

  18. Higgins, J. In preparation.

    Google Scholar 

  19. Asakura, T., Sato, Y., Minakami, S., and Yoshikawa, H., J. Biochem. (Tokyo), 59, 524 (1966).

    CAS  Google Scholar 

  20. Bohr, C., Hasselbalch, K., and Krogh, A., Skand. Arch. Physiol., 16, 402 (1904).

    Google Scholar 

  21. Asakura, T., Sato, Y., Minakami, S., and Yoshikawa, H., Clin. Chim. Acta, 14, 840 (1966).

    Article  CAS  Google Scholar 

  22. Minakami, S., and Yoshikawa, H., J. Biochem. (Tokyo), 59, 145 (1966).

    CAS  Google Scholar 

  23. Rose, I. A. Unpublished observations.

    Google Scholar 

  24. Eckel, R. E., Rizzo, S. C., Lodish, H., and Berggrem, A. B., Amer. J. Physiol., 210, 737 (1966).

    PubMed  CAS  Google Scholar 

  25. Rose, Z. A., J. Biol. Chem., 243, 4810 (1968).

    PubMed  CAS  Google Scholar 

  26. Rose, Z. A. This monograph.

    Google Scholar 

  27. Reich, J. G., Europ. J. Biochem., 6, 395 (1968).

    Article  PubMed  CAS  Google Scholar 

  28. Saito, T., and Minakami, S., J. Biochem. (Tokyo), 61, 211 (1967).

    CAS  Google Scholar 

  29. Asakura, T., Adachi, K., Minakami, S., and Yoshikawa, H., J. Biochem. (Tokyo), 62, 184 (1967).

    CAS  Google Scholar 

  30. Larrson-Razhkiewicz, M., Biochim. Biophys. Acta, 132, 33 (1967).

    Google Scholar 

  31. Melchior, J. B., Biochemistry, 4, 1518 (1965).

    Article  PubMed  CAS  Google Scholar 

  32. Rose, I. A., Proc. Nat. Acad. Sci. U.S.A., 61, 1079 (1968).

    Article  CAS  Google Scholar 

  33. Benesch, R., and Benesch, R. E., Nature, 221, 618 (1969).

    Article  PubMed  CAS  Google Scholar 

  34. Benesch, R. E., Benesch, R., and Yu, C. I., Biochemistry, 8, 2567 (1969).

    Article  PubMed  CAS  Google Scholar 

  35. Benesch, R., Benesch, R. E., and Yu, C. I., Proc. Nat. Acad. Sci. U.S.A., 59, 526 (1968).

    Article  CAS  Google Scholar 

  36. Lo, H. H., and Schimmel, P. R., J. Biol. Chem., 244, 5084 (1969).

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Johnson Research Foundation, University of Penna., Philadelphia, Penna., 19104, USA

    John R. Williamson

Authors
  1. John R. Williamson
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Departments of Human Genetics and Medicine (Simpson Memorial Institute), University of Michigan, Ann Arbor, Michigan, USA

    George J. Brewer M.D. (Conference Chairman) (Conference Chairman)

Rights and permissions

Reprints and permissions

Copyright information

© 1970 Plenum Press, New York

About this chapter

Cite this chapter

Williamson, J.R. (1970). General Features of Metabolic Control as Applied to the Erythrocyte. In: Brewer, G.J. (eds) Red Cell Metabolism and Function. Advances in Experimental Medicine and Biology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3195-7_9

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3195-7_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3197-1

  • Online ISBN: 978-1-4684-3195-7

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation