Abstract
The shift to the right in the oxygen dissociation curve of vigorously exercising subjects beyond that attributable to the decrease in blood pH and/or the increase in blood temperature has been noted by several investigators (Mitchell et al., 1958; Rowell et al., 1964; Sproule and Archer, 1959). The right shift is more pronounced in venous than arterial blood because of the greater decrease in pH (Sproule et al., 1960) and the slight increase in temperature (Sproule and Archer, 1959) of the venous compared to the arterial blood. Mitchell et al., (1958) recognized the potential of the right shift in the oxygen dissociation curve to maintain an adequate tissue oxygen gradient or to increase oxygen unloading at a given tension. However, they concluded that the mechanism was unknown.
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References
Aste-Salazar, H. and Hurtado, A. (1944). Am. J. Physiol. 142:733.
Astrand, I. (1960). Acta Physiol. Scand. 49:Suppl. 169.
Astrand, P.-O., Fallback, I., Hedman, R., and Saltin, B. (1963). J. Appl. Physiol. 18:619.
Astrand, P.-C., and Saltin, B. (1961a). J. Appl. Physiol. 16:971.
Astrand, P.-O., and Saltin, B. (1961b). J. Appl. Physiol. 16:977.
Balke, B. (1963). Proceedings of First Canadian Fitness Seminar 1:5.
Benesch, R., and Benesch, R. E. (1967). Biochem. and Biophys. Res. Commun. 26:162.
Brewer, G. J. and Eaton, J. W. (1969). J. Clin. Invest. (abst.). 48:11a.
Carrow, R. S., Brown, R. E., and Van Huss, W. D. (1967). Anat. Record. 159:33.
Chanutin, A. and Curnish, R. R. (1967). Arch. Biochem. Biophys. 121:96.
Costill, D. L., and Fox, E. L. (1969). Med. Sci. Sports. 1:81.
Christensen, E. H., and Hogberg, P. (1950). Arbeits. 14:292.
Davis, J. E. (1939). J. Lab. Clin. Med. 23:786.
Dill, D. B., Edwards, H. T., and Talbot, J. H. (1935). J. Physiol. (Land.). 69:267.
Eaton, J. W., Brewer, G. J., and Grover, R. F. (1969a). J. Lab. Clin. Med. 73:603.
Eaton, J. W., Faulkner, J. A., and Brewer, G. J. (1969b). Physiologist (abst.). 12:212.
Eaton, J. W., Faulkner, J. A., and Brewer, G. J. (1969c). Proc. Soc. Exp. Biol. (In Press).
Ekblom, B., Astrand, P.-O., Saltin, B., Stenberg, J., Wallstrom, B. (1968). J. Appl. Physiol. 24:518.
Faulkner, J. A. (1968). J. Am. Med. Assoc. 205:741.
Faulkner, J. A. (1970). In Physiology and Biochemistry of Muscle as a Food. Briskey, E. J., Cassens, R. G., Marsh, B. B., Eds. Univ. of Wisconsin Press. (In Press).
Faulkner, J. A., Kollias, J., Favour, C. B., Buskirk, E. R., and Balke, B. (1968). J. Appl. Physiol. 24:685.
Gollnick, P. D., Struck, P. J., Soule, R. G., and Heinrick, J. R. (1965), Arbeits. 21:169.
Gordon, E. E., Kowalski, K., and Fritts, M. (1967). Arch. Phys. Med. Rehab. 48:296.
Hakkila, J. E. (1955). Annales Med. Exper. Biol. Fenniae 33:Suppl. 10.
Henneman, E., and Olson, C. B. (1965). J. Neurophysiol. 28:581.
Hermansen, L., Hultman, E., and Saltin, B. (1967). Acta Physiol. Scand. 71:129.
Hermansen, L., and Saltin, B. (1969). J. Appl. Physiol. 26:31.
Holmgren, A. and Linderholm, H. (1958). Acta Physiol. Scand. 44:203.
Holmgren, A., Mossfeldt, A. R., Sjostrand, T., and Strom, G. (1960). Acta. Physiol. Scand. 50:72.
Hultman, E., Bergstrom, J., and Anderson, N. McLennan (1967). Scand. J. Clin. Lab. Invest. 19:56.
Kjellberg, S. R., Rudle, U., and Sjostrand, T. (1949). Acta Physiol. Scand. 19:146.
Knehr, C. A., Dill, D. B., and Neufeld, W. (1942). Am. J. Physiol. 136:148.
Lenfant, C., Torrance, J., English, E., Finch, C. A., Reynafarje, C., Ramos, J., and Fauru, J. (1968). J. Clin. Invest. 47:2652.
Marbach, E. P., and Weil, M. H. (1967). Clin. Chem. 13:314.
Margaria, R. (1967). In Exercise at Altitude. Margaria, R. Ed. Exerpta Medica Foundation, New York. p. 15.
Margaria, R., Cerretelli, P., and Mangili, E. (1964). J. Appl. Physiol. 19:623.
Margaria, R., Oliva, R. D., Diprampero, P. E., and Cerretelli, P. (1969). J. Appl. Physiol. 26:752.
Merton, P. A. (1956). J. Physiol. 123:553.
Mitchell, J. H., Sproule, B. J., and Chapman, C. B. (1958). J. Clin. Invest. 37:538.
Oscari, L. B., Williams, B. T., and Hertig, B. A. (1968). J. Appl. Physiol. 24:622.
Pollard, M. L., Cureton, T. K., and Greninger, L. (1969). Med. Sci. Sports. 1:70.
Reeves, J. T., Grover, R. F., and Cohn, J. E. (1967). J. Appl. Physiol. 22:546.
Romanul, F. C. A. (1965). Arch. Neurol. 12:497.
Rowell, L. B., Taylor, H. L., Wang, Y., and Carlson, W. S. (1964). J. Appl. Physiol. 19:284.
Saltin, B. and Stenberg, J. (1964). J. Appl. Physiol. 19:833.
Sproule, B. J. and Archer, R. K. (1959). J. Appl. Physiol. 14:983.
Sproule, B. J., Mitchell, J. H., and Miller, W. F. (1960). J. Clin. Invest. 39:378.
Strydom, N. B., Wyndham, C. H., v. Radhenand, M., and Williams, C. G. (1962). Intern. Congr. Physiol. Sci., 22nd, Leiden. P.6.
Taylor, H. L., Buskirk, E. R., and Henschel, A. (1955). J. Appl. Physiol. 8:73.
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Faulkner, J.A., Brewer, G.J., Eaton, J.W. (1970). Adaptation of the Red Blood Cell to Muscular Exercise. In: Brewer, G.J. (eds) Red Cell Metabolism and Function. Advances in Experimental Medicine and Biology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3195-7_15
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DOI: https://doi.org/10.1007/978-1-4684-3195-7_15
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