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Adaptation to Hypoxia

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 6))

Abstract

Hypoxia occurs if the oxygen requirement of the tissues is greater than the oxygen supply. In man at rest the basal requirement is fixed and if supply does not match this demand, normal function is interrupted.

This work was supported by grants HE-06242 and HE-12174 from the National Heart Institute and by the Boeing Employees’ Medical Research Fund.

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References

  • Barcroft, J. (1920). Anoxaemia — Presidential Address. Lancet 199:485–489.

    Google Scholar 

  • Benesch, R., and Benesch, R.E. (1967). The effect of organic phosphates from the human erythrocyte on the allosteric properties of hemoglobin. Biochem. Biophys. Res. Commun. 26:162–167.

    Article  PubMed  CAS  Google Scholar 

  • Benesch, R., Benesch, R.E. and Yu, C.I. (1968). Reciprocal binding of oxygen and diphosphoglycerate by human hemoglobin. Proc. Natl. Acad. Sci. U.S. 59:526–532.

    Article  CAS  Google Scholar 

  • Chanutin, A., and Curnish, R.R. (1967). Effect of organic and inorganic phosphates on the oxygen equilibrium of human erythrocytes. Arch. Biochem. Biophys. 121:96–102.

    Article  PubMed  CAS  Google Scholar 

  • Eaton, J.W., and Brewer, G.J. (1968). The relationship between red cell 2,3-diphosphoglycerate and levels of hemoglobin in the human. Proc. Natl. Acad. Sci. U.S. 61:756–760.

    Article  CAS  Google Scholar 

  • Edwards, M.J., Novy, M.J., Walters, C.L., and Metcalfe, J. (1968). Improved oxygen release: an adaptation of mature red cells to hypoxia. J. Clin. Invest. 47:1851–1857.

    Article  PubMed  CAS  Google Scholar 

  • Kennedy, A.C., and Valtis, D.J. (1954). The oxygen dissociation curve in anemia of various types. J. Clin. Invest. 33:1372–1381.

    Article  PubMed  CAS  Google Scholar 

  • Lenfant, C., Torrance, J., English, E., Finch, C.A., Reynafarje, C., Ramos, J., and Faura, J. (1968). Effect of altitude on oxygen binding by hemoglobin and on organic phosphate levels. J. Clin. Invest. 47:2652–2656.

    Article  PubMed  CAS  Google Scholar 

  • Lenfant, C., Ways, P., Aucutt, C., and Cruz, J. (1969). Effect of chronic hypoxic hypoxia on the O2-Hb dissociation curve and respiratory gas transport in man. Respir. Physiol. 7:7–29.

    Article  PubMed  CAS  Google Scholar 

  • Metcalfe, J., Dhindsa, D.G., Edwards, M.J., and Mourdjinis, A. (1969). Decreased affinity of blood for oxygen in patients with low-output heart failure. Circulation Research 25:47–51.

    PubMed  CAS  Google Scholar 

  • Morse, M., Cassels, D.E., and Holder, M. (1950). The position of the oxygen dissociation curve of the blood in cyanotic congenital heart disease. J. Clin. Invest. 29:1098–1103.

    Article  PubMed  CAS  Google Scholar 

  • Mulhausen, R., Astrup, P., and Kjeldsen, K. (1967). Oxygen affinity of hemoglobin in patients with cardiovascular diseases, anemia, and cirrhosis of the liver. Scand. J. Clin. Lab. Invest. 19:291–297.

    Article  CAS  Google Scholar 

  • Rodman, T., Close, H.P., and Purcell, M.K. (1960). Oxyhemoglobin dissociation curve in anemia. Ann. Intern. Med. 52:295–309.

    PubMed  CAS  Google Scholar 

  • Torrance, J.D., Jacobs, P., Restrepo, A., Eschbach, J., Lenfant, C. and Finch, C.A. (in preparation). Intraerythrocytic adaptation to anemia.

    Google Scholar 

  • Woodson, R.D., Torrance, J.D., and Lenfant, C. (1969). Oxygen transport in low cardiac output hypoxia. Physiologist 12:399.

    Google Scholar 

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© 1970 Plenum Press, New York

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Lenfant, C., Torrance, J.D., Woodson, R., Finch, C.A. (1970). Adaptation to Hypoxia. In: Brewer, G.J. (eds) Red Cell Metabolism and Function. Advances in Experimental Medicine and Biology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3195-7_14

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  • DOI: https://doi.org/10.1007/978-1-4684-3195-7_14

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3197-1

  • Online ISBN: 978-1-4684-3195-7

  • eBook Packages: Springer Book Archive

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