Abstract
A new physiological system for the regulation of the oxygen affinity to hemoglobin has been discovered during the last two years. Addition of 2,3-diphosphoglycerate (DPG) and adenosine triphosphate (ATP) to dilute hemoglobin solutions dramatically decreased the affinity of the hemoglobin for oxygen (Benesch & Benesch, 1967; Chanutin and Curnish, 1967) and a close inverse relation was found (Akerblom et al., 1968; Engel & Duc, 1968; Lenfant et al., 1968) between the oxygen affinity and the concentration of these phosphocompounds in intact human erythrocytes.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Akerblom, O., deVerdier, C.-H., Garby, L. and Hogman, C. (1968). Scand. J. Clin. Lab. Invest. 21:245.
Benesch, R., Benesch, R.E. and Yu, C.I. (1968). Proc. Nat. Acad. Sci. 59:526.
Benesch, R. and Benesch, R.E. (1969). Nature 221:618.
Benesch, R.E., and Benesch, R., and Yu. C.I. (1969). Biochemistry 8:2567.
Benesch, R. and Benesch, R.E. (1967). Biochem. Biophys. Res. Comm. 26:162.
Chanutin, A. and Curnish, R.R. (1967). Arch. Biochem. Biophys. 121:96.
Chanutin, A. and Hermann, E. (1969). Arch. Biochem. Biophys. 131:180.
deVerdier, C.-H. and Garby, L. (1969). Scand. J. Clin. Lab. Invest. 23:149.
deVerdier, C.-H., Garby, L. and Hjelm, M. (1969). Acta Soc. Med. Upsal. In press.
Engel, K. and Duc, G. (1968). Nature 219:936.
Garby, L., Gerber, G. and deVerdier, C-H. (1968). In Stoffwechsel und Membranpermeabilitaet von Erytrhocyten und Thrombocyten. G. Thieme, Stuttgart, 1968.
Garby, L., Gerber, G. and deVerdier, C-H. (1969). Europ. J. Biochem. 10:110.
Hamilton, H.B., Iuchi, I., Miyaji, T. and Shibata, S. (1969). J. Clin. Invest. 48:525.
Lenfant, C., Torrance, J., English, G.; Finch, C.A., Reynfarje, C., Ramos, J. and Faura, J. (1968)., J. Clin. Invest. 47:2652.
Muirhead, H., Cox, J.M., Mazzarella, L. and Perutz, M. (1967). J. Mol. Biol. 28:117.
Weed, R.I., LaCelle, P.L. and Merrill, E.W. (1969). J. Clin. Invest. 48:795.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1970 Plenum Press, New York
About this chapter
Cite this chapter
Garby, L., de Verdier, CH. (1970). Binding of Organic Phosphates to Hemoglobin A and Hemoglobin F. In: Brewer, G.J. (eds) Red Cell Metabolism and Function. Advances in Experimental Medicine and Biology, vol 6. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3195-7_1
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3195-7_1
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3197-1
Online ISBN: 978-1-4684-3195-7
eBook Packages: Springer Book Archive