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Germinal Centers and Immunological Memory

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Book cover Lymphatic Tissue and Germinal Centers in Immune Response

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 5))

Abstract

Recent theories dealing with immunologically competent cells favor the idea that a major difference between primary and secondary responses lies in the much larger number of cells responding after a secondary than after a primary exposure to a given antigen. Experimental evidence has been put forth [1] to show that, in the spleens of mice, the number of immunologically competent cells reacting to a specific antigen, such as heterologous erythrocytes, is 100-fold larger during the secondary than during the primary response. Histological observations on the lymphoid tissues draining the sites of antigen injections also support this concept, since many more large lymphoid blast cells and antibody-forming cells arise within a few days after a secondary than after a primary injection of antigen [2–4].

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Authors and Affiliations

  1. Department of Pathology, New York University School of Medicine, New York, New York, USA

    G. J. Thorbecke

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  1. G. J. Thorbecke
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Editors and Affiliations

  1. Institute of Pathological Anatomy, University of Padua, Padua, Italy

    L. Fiore-Donati

  2. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    M. G. Hanna Jr.

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© 1969 Plenum Press

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Thorbecke, G.J. (1969). Germinal Centers and Immunological Memory. In: Fiore-Donati, L., Hanna, M.G. (eds) Lymphatic Tissue and Germinal Centers in Immune Response. Advances in Experimental Medicine and Biology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3192-6_9

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  • DOI: https://doi.org/10.1007/978-1-4684-3192-6_9

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3194-0

  • Online ISBN: 978-1-4684-3192-6

  • eBook Packages: Springer Book Archive

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