Abstract
The antibody synthesizing cell is specifically differentiated toward the production of an immunoglobulin belonging to a single class, exhibiting only one allelic allotypic specificity for each locus and probably possessing a single antibody activity [1, 2, 3, 4]. The antigenic stimulus is known to induce a complex set of events, including proliferation of immunocompetent cells [5, 6, 7, 8], in lymphopoietic tissue. If the specific differentiation is preserved through cell generations, the immunopoietic tissue should be constituted by more or less delimited clusters of cells sharing a common pattern of differentiation.
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Carbonara, A.O., Luzzati, A.L., Tosi, R.M., Mancini, G., Ceppellini, R. (1969). Clonal Compartmentation in the Antibody-Producing Lymph Node. In: Fiore-Donati, L., Hanna, M.G. (eds) Lymphatic Tissue and Germinal Centers in Immune Response. Advances in Experimental Medicine and Biology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3192-6_46
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DOI: https://doi.org/10.1007/978-1-4684-3192-6_46
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