Abstract
In various species, lacy networks of immunoglobulins have been demonstrated in most germinal centers by immunofluorescence [1]. In the majority of cases these immunoglobulins are mixtures of molecules of different class, type, and allotype (see Pernis [2]) and are located in intercellular spaces, particularly close to membranes of the dendritic macrophages present in the centers. These intercellular deposits of immunoglobulins dominate the pattern demonstrable with fluorochrome-conjugated antisera and constitute an obstacle to the study of intracellular immunoglobulins actively synthesized by individual cells of the germinal centers.
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Pernis, B., Governa, M., Scelsi, R., Maura, E., Ferrarini, M. (1969). Absence of Complement Binding by Immunoglobulin Aggregates in Germinal Centers. In: Fiore-Donati, L., Hanna, M.G. (eds) Lymphatic Tissue and Germinal Centers in Immune Response. Advances in Experimental Medicine and Biology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3192-6_45
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DOI: https://doi.org/10.1007/978-1-4684-3192-6_45
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