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Detection of Virus Particles in Lymphatic Tissue Germinal Centers

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Lymphatic Tissue and Germinal Centers in Immune Response

Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 5))

Abstract

We previously reported the detection by electron microscopy of many C-type murine leukemia virus particles in lymphatic tissue (spleen, mesenteric lymph node) germinal -centers of C58 mice [1]. Virus particles were observed in germinal centers of this high leukemic mouse strain (>90% by 14 months old) between 3 and 9 months, or throughout the relatively long period of leukemia development, C-type virus particles were not restricted to germinal centers of the spleen and lymph nodes; however, their abundance in these sites was pronounced. Subsequently, the detection of viruslike particles in germinal centers of another species, nonleukemic Hartley strain guinea pigs, has been reported [2].

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References

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Author information

Author notes

  1. D. C. Swartzendruber

    Present address: Medical Division, Oak Ridge Associated Universities, P. O. Box 117, Oak Ridge, Tennessee, 37830, USA

Authors and Affiliations

  1. Department of Microbiology, University of Michigan, Ann Arbor, Michigan, USA

    D. C. Swartzendruber, Booe Il Ma & W. H. Murphy

Authors
  1. D. C. Swartzendruber
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  2. Booe Il Ma
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  3. W. H. Murphy
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Editor information

Editors and Affiliations

  1. Institute of Pathological Anatomy, University of Padua, Padua, Italy

    L. Fiore-Donati

  2. Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA

    M. G. Hanna Jr.

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© 1969 Plenum Press

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Swartzendruber, D.C., Ma, B.I., Murphy, W.H. (1969). Detection of Virus Particles in Lymphatic Tissue Germinal Centers. In: Fiore-Donati, L., Hanna, M.G. (eds) Lymphatic Tissue and Germinal Centers in Immune Response. Advances in Experimental Medicine and Biology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3192-6_22

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  • DOI: https://doi.org/10.1007/978-1-4684-3192-6_22

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3194-0

  • Online ISBN: 978-1-4684-3192-6

  • eBook Packages: Springer Book Archive

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