Abstract
Studies performed in our laboratory on the kinetics of immunological memory in isolated and transferred lymphoid cell populations have established that memory decays with a half-life of about 200 days, or about one-sixth of life-span. The high degree of radio-sensitivity of the memory, regardless of the time of irradiation (e.g., before or after the transfer), led us to interpret it as mediated by the presence of a specifically determined, slowly declining cell line, endowed with the capacity (when restimulated by the antigen) to give rise to rapidly dividing, antibody-producing cell lines [1].
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
F. Celada, J. Exptl. Med., 125:199, 1967.
S. Britton and F. Celada, Immunology, 14:503, 1968.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1969 Plenum Press
About this chapter
Cite this chapter
Britton, S., Celada, F. (1969). Immunogenicity Decay of Foreign Antigens in the Mouse. In: Fiore-Donati, L., Hanna, M.G. (eds) Lymphatic Tissue and Germinal Centers in Immune Response. Advances in Experimental Medicine and Biology, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3192-6_21
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3192-6_21
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3194-0
Online ISBN: 978-1-4684-3192-6
eBook Packages: Springer Book Archive