Catecholamines in Regulation of Motor Function

  • K. G. Lloyd
  • O. Hornykiewicz


The function of the catecholamines, dopamine (DA) and noradrenaline (NA), in the control of movement encompasses a large field of physiology and pathology. However, in the examination of CNS function direct investigation of the “normal” state is difficult, if not impossible, and the information available is often the result of the examination of pathological or druginduced conditions. In the study of movement disorders, two syndromes are prominent: Parkinson’s disease and Huntington’s disease. It is from the study of these two syndromes (with emphasis on the former) that the present concepts of catecholamines and motor behavior have evolved. From these studies animal models for the central control of movement have been developed.


Locomotor Activity Motor Function Substantia Nigra Caudate Nucleus Stereotyped Behavior 
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Copyright information

© Plenum Press, New York 1975

Authors and Affiliations

  • K. G. Lloyd
    • 1
  • O. Hornykiewicz
    • 2
  1. 1.Department of PharmacologyUniversity of TorontoTorontoCanada
  2. 2.Department of PsychopharmacologyClarke Institute of PsychiatryTorontoCanada

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