Synergistic Interaction of Cephalosporins and Human Serum on Gram-Negative Bacteria

Orsolini, P.; Milani, M. R.

doi:10.1007/978-1-4684-3126-1_37

P. Orsolini³ &
M. R. Milani³

Part of the book series: Chemotherapy ((CT,volume 5))

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Summary

Different kinds of interaction have been observed when certain antibiotics were added to serum. Chloramphenicol and demethyl-chlortetracycline showed a negative interaction while streptomycin did not significantly change the activity of guinea pig serum against E.coli. Cephalexin and cephaloridine showed synergistic interactions with guinea pig and human serum against E.coli. Heat inactivation, ultrafiltration, bentonite-absorption of serum did not abolish the synergistic effect with cephaloridine.

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References

Adam, D., (1973), in: “Non-Specific” Factors Influencing Host Resistance, eds. W.Braun and J.Ungar ( Karger, Basel ), p. 452.
Google Scholar
Adam, D., (1975), Infection, 3, 44.
Article CAS Google Scholar
Forsgren, A., Gnarpe, H., (1973), Nature New Biol., 244, 82.
PubMed CAS Google Scholar
Friedman, H. et al., (1974), in: Progress in Chemotherapy (Hellenic Soc.Chemotherapy, Athens ), Vol.II, p. 119.
Google Scholar
Toshioka, T. et al., (1971), Nippon Univ.J.Med., 13, 155.
CAS Google Scholar
Traub, W.H., Sherris, J.C., (1970), Chemotherapy, 15, 70.
Article PubMed CAS Google Scholar
Treffers, H.P., Muschel, L.H., (1954), J.Exp.Med., 99, 155.
Article PubMed CAS Google Scholar
Warren, G.H., Gray, J., (1965), Proc.Soc.Exp.Biol.Med., 120, 504.
PubMed CAS Google Scholar
Weisbren, B.A., Brown, I., (1964), Amer.J.Med.Sci., 248, 56.
Article Google Scholar
Zschiesche, W., Augusten, K., (1968), Chemotherapy, 13, 257.
Article PubMed CAS Google Scholar

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Authors and Affiliations

Laboratori Glaxo S.p.A. — Research Division, Verona, Italy
P. Orsolini & M. R. Milani

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P. Orsolini
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M. R. Milani
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Editors and Affiliations

The London Hospital Medical College, London, UK
J. D. Williams
East Birmingham Hospital, Birmingham, UK
A. M. Geddes

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Orsolini, P., Milani, M.R. (1976). Synergistic Interaction of Cephalosporins and Human Serum on Gram-Negative Bacteria. In: Williams, J.D., Geddes, A.M. (eds) Penicillins and Cephalosporins. Chemotherapy, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3126-1_37

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DOI: https://doi.org/10.1007/978-1-4684-3126-1_37
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3128-5
Online ISBN: 978-1-4684-3126-1
eBook Packages: Springer Book Archive

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