Skip to main content
SpringerLink
Log in
Book cover

Penicillins and Cephalosporins pp 191–198Cite as

The Activity of Mecillinam (FL1060), in Combination with Other Antibiotics, Against H. Influenzae and Streptococcus Faecalis

  • Chapter

  • 234 Accesses

Part of the book series: Chemotherapy ((CT,volume 5))

Abstract

Mecillinam, a member of a new group of ß-lactam antibiotics, the 6 — ß amidinopenicillanic acids, has considerable activity against the Enterobacteriacae (Lund & Tybring, 1972). This drug has little activity against the Gram positive organisms and its activity against Haemophilus influenzae has not been fully explored. This study was designed to see if any clinically useful synergistic combinations of other antibiotics together with mecillinam could be found.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Bushby, S.R.M. Trimethoprim–Sulphamethoxazole: In vitro Microbiological aspects. Journal of Infectious Diseases 128: S442–462 (1973).

    Article  CAS  Google Scholar 

  • Elion, G.B., Singer, S., Hitchings, G.H. Antagonists of nucleic acid derivative. Journal of Biological Chemistry 208: 477–488 (1954).

    PubMed  CAS  Google Scholar 

  • Wise, R., and Reeves, D.S. In Press (1975).

    Google Scholar 

  • Tybring, L., Melchior, N.H. In Press (1975).

    Google Scholar 

  • Lund, F. and Tybring, L. 6 ß-amidinopenicillanic acid acids–a new group of antibiotics. Nature, New Biology 236: 135–137 (1972).

    Google Scholar 

  • Melchior, N.H., Blom. J., Tybring, L. and Birch-Anderson, A. Light and Electron Microscopy of the early response of E. coli to a 6 ß3-amidinopenicillanic acid (FL1060). Acta. Path. Microbiol. Scand. 81B: 393–407 (1973).

    CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Medical Microbiology, Dudley Road Hospital, Birmingham, Bl8 7QH, UK

    R. Wise, G. A. J. Ayliffe, J. M. Andrews & K. A. Bedford

Authors
  1. R. Wise
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. G. A. J. Ayliffe
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. J. M. Andrews
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. K. A. Bedford
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. The London Hospital Medical College, London, UK

    J. D. Williams

  2. East Birmingham Hospital, Birmingham, UK

    A. M. Geddes

Rights and permissions

Reprints and permissions

Copyright information

© 1976 Plenum Press, New York

About this chapter

Cite this chapter

Wise, R., Ayliffe, G.A.J., Andrews, J.M., Bedford, K.A. (1976). The Activity of Mecillinam (FL1060), in Combination with Other Antibiotics, Against H. Influenzae and Streptococcus Faecalis. In: Williams, J.D., Geddes, A.M. (eds) Penicillins and Cephalosporins. Chemotherapy, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3126-1_30

Download citation

  • DOI: https://doi.org/10.1007/978-1-4684-3126-1_30

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3128-5

  • Online ISBN: 978-1-4684-3126-1

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation