Abstract
Mecillinam (FL.1060, Leo Laboratories; 6B-(hexahydro-1Hazepin-l-yl)-methyleneamino-penicillanic acid) is a new class of semi-synthetic penicillin derivatives characterised by the presence of a 6B-amidino substitution in the penicillanic acid nucleus. Preliminary studies indicated a high degree of activity against Gram negative bacteria (Lund and Tybring, 1972). It was decided therefore to assess the activity of mecillinam in the laboratory particularly with a view to its use in infections of the urinary tract.
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References
Lund, F., and Tybring, L. Nature New Biology 236, 135–136 (1972).
Greenwood, D., and O’Grady, F. J. Clin.Path. 26, 1–6 (1973).
Greenwood, D., Brooks, H.L., Gargan, R., and O’Grady, F. J. Clin. Path. 27, 192 - 197 (1974).
Reeves, D.S., Wise, R., and Bywater, M.J. Journal of Antimicrobial Chemotherapy, 1974 (in press).
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© 1976 Plenum Press, New York
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Reeves, D.S., Wise, R., Bywater, M.J., Stern, S.R. (1976). Mecillinam: Factors Affecting in Vitro Activity. In: Williams, J.D., Geddes, A.M. (eds) Penicillins and Cephalosporins. Chemotherapy, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3126-1_29
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DOI: https://doi.org/10.1007/978-1-4684-3126-1_29
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3128-5
Online ISBN: 978-1-4684-3126-1
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