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Plasma Profile & Urinary Excretion of Mecillinam after Pivmecillinam

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Penicillins and Cephalosporins

Part of the book series: Chemotherapy ((CT,volume 5))

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Abstract

Pivmecillinam (F.L. 1039. Leo) is the pivaloyloxymethyl ester of mecillinam (F.L. 1060. Leo). Like the related pivampicillin, which is the pivaloyloxy methyl ester of ampicillin, pivmecillinam is biologically inactive Until in-vivo hydrolysis to its biologically active constituent mecillinam. These reactions are shown in Fig. 1.

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References

  1. Parsons, R.L., Bywater, M.J. and Marshall, M. (1974) The absorption of cephalexin and three aminobenzylpenicillins in adult coeliac disease. Progress in Chemotherapy. Proceedings of the 8th International Congress of Chemotherapy. (1973). Vol 1. 534–542. Edit. G. Daikos. Published by the Hellenic Society for Chemotherapy. Athens.

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  2. Parsons, R.L. Hossack, G. and Paddock, G. (1975) The absorption of antibiotics in adult patients with coeliac disease. Journal of Antimicrobial Chemotherapy. 1, 39–50.

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  4. Grove, D.C. and Randall, W.A. Assay methods of antibiotics. A laboratory manual. Medical Encyclopedia Inc. New York. (1955).

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  5. Parsons, R.L. Hossack, G.M. and Paddock, G.M. (1975) Absorption of aminobenzylpenicillins and cephalexin in normal subjects whilst starved and with a Lundh test meal. Journal of Antimicrobial Chemotherapy. 2, in press.

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Author information

Authors and Affiliations

  1. Dept. Clinical Pharmacology, Guy’s Hospital Medical School, London, SE1.9RT, UK

    R. L. Parsons, Gillian M. Hossack & Gillian M. Paddock

Authors
  1. R. L. Parsons
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  2. Gillian M. Hossack
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  3. Gillian M. Paddock
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Editor information

Editors and Affiliations

  1. The London Hospital Medical College, London, UK

    J. D. Williams

  2. East Birmingham Hospital, Birmingham, UK

    A. M. Geddes

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© 1976 Plenum Press, New York

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Parsons, R.L., Hossack, G.M., Paddock, G.M. (1976). Plasma Profile & Urinary Excretion of Mecillinam after Pivmecillinam. In: Williams, J.D., Geddes, A.M. (eds) Penicillins and Cephalosporins. Chemotherapy, vol 5. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3126-1_28

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  • DOI: https://doi.org/10.1007/978-1-4684-3126-1_28

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3128-5

  • Online ISBN: 978-1-4684-3126-1

  • eBook Packages: Springer Book Archive

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