Abstract
Inhibition of antibody and antibody-dependant immune reactions by monovalent haptens is a well known phenomenonv(1) and has been suggested for prevention of immediate allergic reactions(1,2,3). The practical application of an inhibiting monovalent penicilloyl hapten to prevent immediate-type allergic reaction to penicillin in patients allergic to this group of drugs was initiated by de Weck and Schneider(4) and by de Weck and Girard(5) a few years ago. Based on experimental data indicating the a N-e-benzyl-a-formyl-L-lysine derivative (Ro 6–0787 or BPO-FLYS) is structurally optimally fitting the antibody combining sites of antibenzylpenicillin-anti-bodies, and efficiently inhibits various antibody-rdependant allergic reactions in animals sensitized to penicillin4(4).
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Clinical Data Sheet Ro 6–0787 of F. Hoffmann-La Roche & Co. Ltd.
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Vonlanthen, M.C., Jeunet, F., Schulz, K.H., Girard, J.P. (1976). Clinical Trial of a Monovalent Benzylpenicilloyl Hapten Inhibitor (Ro 6–0787) In Penicillin Allergy. In: Williams, J.D., Geddes, A.M. (eds) Pharmacology of Antibiotics. Chemotherapy, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3123-0_50
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DOI: https://doi.org/10.1007/978-1-4684-3123-0_50
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