Summary
The lipid-soluble methoxymethyl ester of hetacillin was found to penetrate well into the prostatic fluid of dogs. The prostatic fluid ampicillin concentrations following intravenous infusion of the ester were approximately 15 times higher than following intravenous infusion of ampicillin in equivalent amounts and were approximately 1/2 of the simultaneous blood concentrations. The bactericidal effect of the prostatic fluid following hetacillin ester administration is demonstrated in vitro.
Keywords
- Intravenous Infusion
- Constant Infusion
- Recurrent Urinary Tract Infection
- Lipid Solubility
- Ampicillin Activity
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Bristol Laboratories, Syracuse, New York. 1975. Inform. Manual.
Meares, E. M. and Stamey, T. A. (1968) Investigative Urology 5, 492.
Winningham, D. G., Nemoy, N. J. and Stamey, T. A. (1968). Nature 219, 139.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 1976 Plenum Press, New York
About this chapter
Cite this chapter
Kjaer, T.B., Madsen, P.O. (1976). The Excretion of Hetacillin Methoxymethyl Ester (BL-P1761) into the Prostatic Fluid of the Dog. In: Williams, J.D., Geddes, A.M. (eds) Pharmacology of Antibiotics. Chemotherapy, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3123-0_34
Download citation
DOI: https://doi.org/10.1007/978-1-4684-3123-0_34
Publisher Name: Springer, Boston, MA
Print ISBN: 978-1-4684-3125-4
Online ISBN: 978-1-4684-3123-0
eBook Packages: Springer Book Archive