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Pharmacology of Antibiotics pp 141–150Cite as

Sisomicin: Serum Half-Life and Distribution Space in Patients with Normal and Impaired Renal Function

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Part of the book series: Chemotherapy ((CT,volume 4))

Abstract

Sisomicin, a new aminoglykoside antibiotic, is now beeing introduced for clinical trials in the treatment of urinary tract infections. The purpose of this study was to determine some data of the pharmacokinetics in patients with normal and impaired renal function and to develop guidlines for appropriate dosage regimens for patients with renal insufficiency and in case of hemodialysis.

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References

  1. Black, J., Calesnick, B., Williams, D., Weinstein, M. J.: Pharmacology of gentamicin, a new broad-spectrum antibiotic; Antimicrob. Ag. Chemother: 138, 1963.

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  2. Grodon, R. C., Regamey, W. M., Kirby, M.: Serum proteinbinding of the aminoglycoside antibiotics. Antimicrob. Ag. Chemother: 214, 1972.

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  3. Gyselynck, A.-M., Forrey, A., Cutler, R.: Pharmacokinetics of gentamicin: distribution and plasma and renal clearance. J. Inf. Dis. 124 Suppl.: 70, 1971.

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  4. Hodd, B., Attman, P., Ahlmen, J., Jagenburg, R.: Renal hemodynamics and limitations of creatinine clearance in determining filtration rate in glomerular disease. Scand. J. Urol. Nephrol. 5: 154, 1971.

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  5. Naber, K. G., Westerfelder, S. R., Madsen, P. O.: Pharmacokinetics of the aminoglycoside antibiotic tobramycin in humans. Antibmicrob. Ag. Chemother. 3: 469, 1973.

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  6. Sigman, E. M., Elwood, C. M. and Knox, F.: The measurement of glomerular filtration rate in man with sodium iothalamate131 I (Conray). J. Nucl. Med. 7: 60, 1965.

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Authors and Affiliations

  1. Departments of Medicine and Urology, University of Marburg., Wuppertal, Germany

    S. Roth, K. G. Naber, M. Scheer & H. Lange

  2. Pharma Forschungszentrum, Bayer AG, Wuppertal, Germany

    S. Roth, K. G. Naber, M. Scheer & H. Lange

Authors
  1. S. Roth
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  2. K. G. Naber
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  3. M. Scheer
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  4. H. Lange
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Editor information

Editors and Affiliations

  1. The London Hospital Medical College, London, UK

    J. D. Williams

  2. East Birmingham Hospital, Birmingham, UK

    A. M. Geddes

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© 1976 Plenum Press, New York

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Roth, S., Naber, K.G., Scheer, M., Lange, H. (1976). Sisomicin: Serum Half-Life and Distribution Space in Patients with Normal and Impaired Renal Function. In: Williams, J.D., Geddes, A.M. (eds) Pharmacology of Antibiotics. Chemotherapy, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3123-0_20

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  • DOI: https://doi.org/10.1007/978-1-4684-3123-0_20

  • Publisher Name: Springer, Boston, MA

  • Print ISBN: 978-1-4684-3125-4

  • Online ISBN: 978-1-4684-3123-0

  • eBook Packages: Springer Book Archive

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