Abstract
Pharmacology as a way of thinking can contribute much to practical medicine. One of these contributions is that it has been shown in animal and in vitro experiments that for nearly all drugs a quantitative relation-ship exists between dose, or better concentration, and effect. Moreover, concentrations lower than so called threshold concentrations exert no effect at all, while at the other end a maximal effect can be found which depends on the characteristics of the interaction of drug and receptor. This maximal effect cannot be exceeded by much higher concentrations.
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References
M. Barza and L. Weinstein, J. of Inf. Dis., 129, p. 73, 1974.
H. Mattie et al., J. of Inf. Dis., 128, 170, 1973.
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© 1976 Plenum Press, New York
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Mattie, H. (1976). The In Vivo Significance of Antibiotics in the Tissues. In: Williams, J.D., Geddes, A.M. (eds) Pharmacology of Antibiotics. Chemotherapy, vol 4. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3123-0_2
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DOI: https://doi.org/10.1007/978-1-4684-3123-0_2
Publisher Name: Springer, Boston, MA
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