Summary
All four colony types of N. gonorrhoeae possess pit-like structures in the outer membrane of their envelopes. A stable, piliated strain GC1 of intermediate colony morphology also possesses this structural feature. Isolated envelopes of gonococcal strain GC1 and T1 have an active D-alanine carboxypeptidase. This membrane-bound enzyme in GC1 has an alkaline pH optimum, a Km of 0. 25 mM and is sensitive to inhibition by penicillin G, ampicillin, cloxacillin and methicillin. An active phospholipase A is present in GC1, Ti and T4 envelopes, the activity is stimulated by methanol (30%) and the enzyme converts phosphatidylethanolamine to lysophosphatidylethanolamine. It is suggested that such an enzyme could modulate barrier properties of the outer membrane.
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© 1976 Plenum Press, New York
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Salton, M.R.J., Kim, K.S., Davis, R., Cho, K.Y. (1976). Surface Structures and Antibiotic Targets in the Gonococcus. In: Williams, J.D., Geddes, A.M. (eds) Special Problems in Chemotherapy. Chemotherapy, vol 3. Springer, Boston, MA. https://doi.org/10.1007/978-1-4684-3120-9_18
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DOI: https://doi.org/10.1007/978-1-4684-3120-9_18
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